Yongjie Yang

TL;DR: The findings constitute the first evidence of the regulation of Complex II activity by the reversible acetylation of the SdhA subunit as a novel substrate of the NAD(+)-dependent deacetylase, SIRT3.

TL;DR: The findings constitute the first evidence for the regulation of mitochondrial protein synthesis by the reversible acetylation of the mitochondrial ribosome and characterize MRPL10 as a novel substrate of the NAD+-dependent deacetylase, SIRT3.

TL;DR: It is shown that estrogen replacement substantially suppresses binge-like eating behavior in ovariectomized female mice and suggests ERα and/or SK current in DRN 5-HT neurons as potential targets for anti-binge therapies.

TL;DR: The 5-HT2CR population in DA neurons is identified as one potential target for antibinge therapies, and preclinical evidence that 5- HT2CR agonists could be used to treat binge eating is provided.

TL;DR: The results support a model where ERα signals activate MeA neurons to stimulate physical activity, which in turn prevents body weight gain, and designer receptors exclusively activated by designer drug-mediated (DREADD) activation of these neurons increased physical activity in mice.