Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز

http://chemistry-chemists.com/chemister/Spravochniki/handbook-of-solubility-data-for-pharmaceuticals-2010.pdf

Handbook of Solubility Data for Pharmaceuticals

Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: Recent developments and future perspective

A review of the innovations in metal- and carbon-based catalysts explored for heterogeneous peroxymonosulfate (PMS) activation, with focus on radical vs. non-radical degradation pathways of organic contaminants

We present a new and considerably extended parameterization of the thermodynamic activity coefficient model AIOMFAC (Aerosol Inorganic-Organic Mixtures Functional groups Activity Coefficients) at room temperature. AIOMFAC combines a Pitzer-like electrolyte solution model with a UNIFAC-based group-contribution approach and explicitly accounts for interactions between organic functional groups and inorganic ions. Such interactions constitute the salt-effect, may cause liquid-liquid phase separation, and affect the gas-particle partitioning of aerosols. The previous AIOMFAC version was parameterized for alkyl and hydroxyl functional groups of alcohols and polyols. With the goal to describe a wide variety of organic compounds found in atmospheric aerosols, we extend here the parameterization of AIOMFAC to include the functional groups carboxyl, hydroxyl, ketone, aldehyde, ether, ester, alkenyl, alkyl, aromatic carbon-alcohol, and aromatic hydrocarbon. Thermodynamic equilibrium data of organic-inorganic systems from the literature are critically assessed and complemented with new measurements to establish a comprehensive database. The database is used to determine simultaneously the AIOMFAC parameters describing interactions of organic functional groups with the ions H^+, Li^+, Na^+, K^+, NH_(4)^+, Mg^(2+), Ca^(2+), Cl^−, Br^−, NO_(3)^−, HSO_(4)^−, and SO_(4)^(2−). Detailed descriptions of different types of thermodynamic data, such as vapor-liquid, solid-liquid, and liquid-liquid equilibria, and their use for the model parameterization are provided. Issues regarding deficiencies of the database, types and uncertainties of experimental data, and limitations of the model, are discussed. The challenging parameter optimization problem is solved with a novel combination of powerful global minimization algorithms. A number of exemplary calculations for systems containing atmospherically relevant aerosol components are shown. Amongst others, we discuss aqueous mixtures of ammonium sulfate with dicarboxylic acids and with levoglucosan. Overall, the new parameterization of AIOMFAC agrees well with a large number of experimental datasets. However, due to various reasons, for certain mixtures important deviations can occur. The new parameterization makes AIOMFAC a versatile thermodynamic tool. It enables the calculation of activity coefficients of thousands of different organic compounds in organic-inorganic mixtures of numerous components. Models based on AIOMFAC can be used to compute deliquescence relative humidities, liquid-liquid phase separations, and gas-particle partitioning of multicomponent mixtures of relevance for atmospheric chemistry or in other scientific fields.

/pdf/new-and-extended-parameterization-of-the-thermodynamic-model-1xzpgxcqvj.pdf

New and extended parameterization of the thermodynamic model AIOMFAC: calculation of activity coefficients for organic-inorganic mixtures containing carboxyl, hydroxyl, carbonyl, ether, ester, alkenyl, alkyl, and aromatic functional groups

A compendium of phase change enthalpies published in 2010 is updated to include the period 1880–2015. Phase change enthalpies including fusion, vaporization, and sublimation enthalpies are included for organic, organometallic, and a few inorganic compounds. Part 1 of this compendium includes organic compounds from C1 to C10. Part 2 of this compendium, to be published separately, will include organic and organometallic compounds from C11 to C192. Sufficient data are presently available to permit thermodynamic cycles to be constructed as an independent means of evaluating the reliability of the data. Temperature adjustments of phase change enthalpies from the temperature of measurement to the standard reference temperature, T = 298.15 K, and a protocol for doing so are briefly discussed.

Phase Transition Enthalpy Measurements of Organic and Organometallic Compounds. Sublimation, Vaporization and Fusion Enthalpies From 1880 to 2015. Part 1. C1-C10

The solubilities of dexamethasone sodium phosphate in different solvents were measured using a synthetic method. The laser monitoring observation technique was used to determine the disappearance of the solid phase in a solid + liquid mixture. The solubility data were correlated with Apelblat equation.

Solubility of Dexamethasone Sodium Phosphate in Different Solvents

Many drought indices were proposed to describe drought characteristics, but only few had considered environmental changes. In an attempt to incorporate climate change into meteorological drought index, a nonstationary Gamma distribution with climate indices as covariates was developed for fitting precipitation data and then used for calculating a Nonstationary Standardized Precipitation Index (NSPI) in this study. The performances of the NSPI were compared with those of the traditional Standardized Precipitation Index (SPI), showing that the NSPI capable of taking climate variations into account is more robust than the traditional SPI. Focusing on the Luanhe River basin, historical drought events were described and assessed based on the NSPI and traditional SPI. Moreover, drought characteristics, including drought frequency, peak, duration, and magnitude, were calculated by using the two indices. The results in this study indicated that NSPI using climate indices as covariates could capture drought characteristics in the Luanhe River basin, and this new drought index provides a new concept for constructing the drought index that can effectively adapt to a changing environment.

https://agupubs.onlinelibrary.wiley.com/doi/epdf/10.1002/2015JD023920

A Nonstationary Standardized Precipitation Index incorporating climate indices as covariates

Thermodynamic equilibrium of 4-hydroxy-2,5-dimethyl-3(2H)-furanone in different solvent systems

The solubility data of two polymorphs of 2,3,5-trimethyl-1,4-diacetoxybenzene (TMHQ-DA) in ethanol, 1-propanol, 2-propanol, and 1-butanol at various temperatures were experimentally measured using gravimetrical method and correlated by the modified Apelblat model and the van’t Hoff equation, respectively. Differential scanning calorimetry (DSC) and thermogravimetry (TG) analyses were performed to investigate the thermodynamic stability and the transition of the two forms of TMHQ-DA. An enantiotropic relationship was found between TMHQ-DA Form A and TMHQ-DA Form B, and the transition point between them was experimentally determined to be 314.50 ± 1 K. A thermodynamic model for estimation of the transition point was also derived, and the estimated results are satisfactorily consistent with the experimental values. Finally, the accuracy of the transition point obtained in this research was validated by the polymorphic transformation experiments monitored using Raman spectroscopy.

Yongli Wang

Papers

Solubility of Dexamethasone Sodium Phosphate in Different Solvents

A Nonstationary Standardized Precipitation Index incorporating climate indices as covariates

Thermodynamic equilibrium of 4-hydroxy-2,5-dimethyl-3(2H)-furanone in different solvent systems

Solubility and Thermodynamic Stability of the Enantiotropic Polymorphs of 2,3,5-Trimethyl-1,4-diacetoxybenzene

Measurement and correlation of solubility of cefmenoxime hydrochloride in pure solvents and binary solvent mixtures