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Yoshiharu Minamitake
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 4455
Yoshiharu Minamitake is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Particle & Biodegradable polymer. The author has an hindex of 7, co-authored 8 publications receiving 4332 citations.
Papers
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Patent
Biodegradable injectable nanoparticles
TL;DR: In this paper, a biodegradable solid core containing a biologically active material and poly(alkylene glycol) moieties on the surface is provided, which can be modified to achieve variable release rates or to target specific cells or organs.
Patent
Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
TL;DR: In this article, a core of a multiblock copolymer is formed by covalently linking a multifunctional compound with one or more hydrophobic polymers.
Journal ArticleDOI
PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics1
TL;DR: Polyethylene glycol (PEG)-coated nanospheres were prepared in a single step process using amphiphilic diblock and multiblock copolymers, and their drug encapsulation properties and release characteristics were investigated in vitro.
Patent
Biodegradable injectable particles for imaging
TL;DR: The terminal hydroxyl group of the poly(alkylene glycol) can be used to covalently attach onto the surface of the injectable particles, including antibodies targeted to specific cells or organs, or molecules affecting the charge, lipophilicity or hydrophilicity of the particle as discussed by the authors.