Showing papers by "Yoshikazu Inoue published in 2004"
TL;DR: The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection has many limitations, including being confounded by bacillus Calmette-Guerin (BCG) vaccination or exposure to nontuberculous mycobacteria.
Abstract: The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection has many limitations, including being confounded by bacillus Calmette-Guerin (BCG) vaccination or exposure to nontuberculous mycobacteria. M. tuberculosis-specific antigens that are absent from BCG and most nontuberculous mycobacteria have been identified. We examined the use of two of these antigens, CFP-10 and ESAT-6, in a whole blood IFN-gamma assay as a diagnostic test for tuberculosis in BCG-vaccinated individuals. Because of the lack of an accurate standard with which to compare new tests for M. tuberculosis infection, specificity of the whole blood IFN-gamma assay was estimated on the basis of data from people with no identified risk for M. tuberculosis exposure (216 BCG-vaccinated Japanese adults) and sensitivity was estimated on the basis of data from 118 patients with culture-confirmed M. tuberculosis infection who had received less than 1 week of treatment. Using a combination of CFP-10 and ESAT-6 responses, the specificity of the test for the low-risk group was 98.1% and the sensitivity for patients with M. tuberculosis infection was 89.0%. The results demonstrate that the whole blood IFN-gamma assay using CFP-10 and ESAT-6 was highly specific and sensitive for M. tuberculosis infection and was unaffected by BCG vaccination status.
641 citations
TL;DR: The survival rates for adult PAP patients seem to have increased progressively in the four decades since the initial clinical description, and the prognosis for adult patients with PAP varies, but disease-specific survival rate exceeds 80% at 5 years.
79 citations
TL;DR: Serial measurement of neutralizing capacity of GM- CSF was useful to evaluate disease severity and the anti-GM-CSF antibody was proved to be a causative factor for PAR In the future, inhaled GM-CSf may replace whole lung lavage and response to GM- CSI and its optimal amount may be decided by the capacity.
39 citations
TL;DR: It is suggested that E-selectin may be relevant to the pathogenesis of idiopathic pulmonary fibrosis, and it may be a novel clinical parameter for idiopATHic pulmonary Fibrosis.
Abstract: To elucidate the biological significance of selectin for idiopathic pulmonary fibrosis, we titrated the serum soluble E-selectin. From 31 cases of idiopathic pulmonary fibrosis patients without signs or symptoms of infection, the serum was obtained and the concentration was titrated by enzyme-linked immunosorbent assay. The serum soluble E-selectin titer was significantly higher than that of healthy controls. However, significant elevation was not observed in the sera from the patients with other pulmonary diseases, such as pulmonary emphysema, sarcoidosis, or bronchiectasis. In the patients with idiopathic pulmonary fibrosis, the number of white blood cells, C-reactive protein or lactate dehydrogenase activity did not show a significant relationship with the soluble E-selectin titer. About 16 out of the 31 idiopathic fibrosis patients, the serum surfactant apoprotein-A titer, which is a parameter of the disease activity of idiopathic pulmonary fibrosis, was also tested. The surfactant apoprotein-A titer was loosely correlated with the soluble E-selectin titer. These observations suggest that E-selectin may be relevant to the pathogenesis of idiopathic pulmonary fibrosis, and it may be a novel clinical parameter for idiopathic pulmonary fibrosis.
12 citations
Journal Article•
TL;DR: This is the first-ever report documenting the usefulness of IDC for BAE, a mechanically detachable coil allowing the operator to seek the ideal shape until its final release, which is significantly shorter than in the non-IDC group.
Abstract: Bronchial artery embolization (BAE) is almost the only effective nonsurgical treatment for massive hemoptysis. Metallic coils with plastic fibers are widely used as embolic materials. We have introduced an interlocking detachable coil (IDC) for BAE. IDC is a mechanically detachable coil, allowing the operator to seek the ideal shape until its final release. We compared hemoptysis patients treated with conventional metallic coils (24 patients, non-IDC group) with those treated with conventional coils and IDCs (26 patients, IDC group). The hemoptysis rate after three months is significantly lower in the IDC group than in the non-IDC group (7.7% vs. 16.3%, p = 0.035 Fisher's exact method). Total procedure time (in staged or repetitive BAE cases, procedure times are added together) is significantly shorter in the IDC group than in the non-IDC group (3.4 +/- 1.4 hours vs. 4.4 +/- 2.5 hours, p = 0.040 unpaired t-test). IDC is a useful device for BAE. This is the first-ever report documenting the usefulness of IDC for BAE.
6 citations
Journal Article•
TL;DR: A 62-year-old man was referred to the authors' hospital because of persistent sub-fever and a pulmonary fungal infection was suspected owing to the elevation of the serum-D-glucan level.
Abstract: A 62-year-old man was referred to our hospital because of persistent sub-fever. A pulmonary fungal infection was suspected owing to the elevation of the serum-D-glucan level. Since a chest radiograph and a CT scan revealed intrabullous fluid in the right upper lobe, percutaneous needle aspiration was performed. Although acid-fast bacilli smears of the sputum and intrabullous fluid were negative, their cultures were found to be positive thereafter. M. kansasii was isolated and identified. After chemotherapy with antituberculous drugs, sub-fever improved and intrabullous fluid disappeared completely. Infected bulla caused by mycobacteria is very rare.
2 citations