The discovery of antifungal agents that possess selective toxicity against the eukaryotic fungal cell remains an important scientific challenge. The growing medical need for safe and effective antifungal agents stems from the rapidly increasing population of immunocompromise d patients. Although the treat­ ment of fungal infections is progressing steadily, currently available agents act on targets that are also found in mammalian cells. Ideally, a selectively toxic

Antibiotics that Inhibit Fungal Cell Wall Development

Directed lithiation of aromatic tertiary amides: an evolving synthetic methodology for polysubstituted aromatics

The synthetic utility of oxazolines in aromatic substitution

Chapter Two - Naturally Occurring Cyclotryptophans and Cyclotryptamines

Inhibition of acyl-CoA synthetase by triacsins

Total synthesis of amauromine

Chaetiacandin, a novel papulacandin. II. Structure determination.

The structure of new hypotensive vasodilators, WS-1228 A and B, produced by Streptomyces aureofaciens, were determined as 1 and 2, respectively, on the basis of their spectral and chemical evidences.WS-1228 A (1), having N-hydroxytriazene moiety, was synthesized from (E, E, E)-2, 4, 7-undecatrienal (4) by condensation with hydrazine hydrate followed by nitrosation.

Studies on new vasodilators, WS-1228 A and B. II. Structure and synthesis.

The structures of WB-3559 A, B, C and D, new fibrinolytic agents isolated from Flavobacterium sp No 3559, have been elucidated to be as shown in 1, 2, 3 and 4, respectively, on the basis of chemical and spectroscopic evidence Total synthesis of WB-3559 D (4) was achieved starting from the optically active aldehyde 14

https://www.jstage.jst.go.jp/article/antibiotics1968/38/11/38_11_1476/_pdf

Yoshikuni Itoh

Papers

Total synthesis of amauromine

Chaetiacandin, a novel papulacandin. II. Structure determination.

Studies on new vasodilators, WS-1228 A and B. II. Structure and synthesis.

Studies on WB-3559 A, B, C and D, new potent fibrinolytic agents. II. Structure elucidation and synthesis.

Structure and synthesis of a new hypotensive vasodilator isolated from Streptomyces aureofaciens