Y
Yoshimi Ogawa
Researcher at Tottori University
Publications - 2
Citations - 318
Yoshimi Ogawa is an academic researcher from Tottori University. The author has contributed to research in topics: Enzyme activator & Mutant. The author has an hindex of 2, co-authored 2 publications receiving 307 citations.
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Journal ArticleDOI
Chemical chaperone therapy for brain pathology in GM1-gangliosidosis
Junichiro Matsuda,Osamu Suzuki,Akihiro Oshima,Yoshie Yamamoto,Akira Noguchi,Kazuhiro Takimoto,Masayuki Itoh,Yuji Matsuzaki,Yosuke Yasuda,Seiichiro Ogawa,Yuko Sakata,Eiji Nanba,Katsumi Higaki,Yoshimi Ogawa,Lika Tominaga,Kousaku Ohno,Hiroyuki Iwasaki,Hiroshi Watanabe,Roscoe O. Brady,Yoshiyuki Suzuki +19 more
TL;DR: A galactose derivative synthesized for chemical chaperone therapy of a human neurogenetic disease, β-galactosidosis, resulted in significant enhancement of the enzyme activity in the brain and other tissues and a marked decrease of intracellular substrate storage.
Journal ArticleDOI
Galactonojirimycin derivatives restore mutant human β-galactosidase activities expressed in fibroblasts from enzyme-deficient knockout mouse
Lika Tominaga,Yoshimi Ogawa,Megumi Taniguchi,Kousaku Ohno,Junichiro Matsuda,Akihiro Oshima,Yoshiyuki Suzuki,Eiji Nanba +7 more
TL;DR: Low molecular compounds analogous to galactose restored mutant enzyme activities expressed in enzyme-deficient knockout mouse fibroblasts and human beta-galactosidosis fibro Blasts at lower intracellular concentrations and it is hoped that this new therapeutic approach will become clinically applicable in the near future.