Y
Yoshinobu Kimura
Researcher at Gifu University of Medical Science
Publications - 20
Citations - 617
Yoshinobu Kimura is an academic researcher from Gifu University of Medical Science. The author has contributed to research in topics: Virus & Herpes simplex virus. The author has an hindex of 11, co-authored 20 publications receiving 556 citations.
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Journal ArticleDOI
Olfactory transmission of neurotropic viruses
TL;DR: The authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health.
Journal ArticleDOI
Reactivation of HSV‐1 in the brain of patients with familial Alzheimer's disease
Isamu Mori,Yoshinobu Kimura,Hironobu Naiki,Rokuro Matsubara,T. Takeuchi,Takashi Yokochi,Yukihiro Nishiyama +6 more
TL;DR: This report provides the first evidence of reactivation of HSV‐1 in the brain of patients with familial Alzheimer's disease, associated with β‐amyloid deposition, and suggests the possible involvement of HSv‐1 together with genetic factors in the pathogenesis of familial Alzheimer’s disease.
Journal ArticleDOI
Oral vaccination with a liposome‐encapsulated influenza DNA vaccine protects mice against respiratory challenge infection
TL;DR: The results suggest that gastrointestinal tract, a constituent member of the common mucosal immune system, is a potent candidate applicable as a DNA vaccine route against virus respiratory diseases.
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The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus
Isamu Mori,Fumi Goshima,Hiroyasu Ito,Naoki Koide,Tomoaki Yoshida,Takashi Yokochi,Yoshinobu Kimura,Yukihiro Nishiyama +7 more
TL;DR: The results suggest that neurotropic viruses can invade the brain by infecting vomeronasal chemosensory neurons and that the restrained induction of apoptosis in the infected neurons may facilitate viral transmission to the CNS.
Journal ArticleDOI
Virus-induced neuronal apoptosis as pathological and protective responses of the host
TL;DR: A novel concept can be proposed that virus‐induced neuronal apoptosis in the central nervous system may represent a pathological host response, while that in the peripheral counterpart, especially olfactory receptor neurons, may mediate a protective host response.