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Yoshinobu Kimura
Researcher at Gifu University of Medical Science
Publications - 20
Citations - 617
Yoshinobu Kimura is an academic researcher from Gifu University of Medical Science. The author has contributed to research in topics: Virus & Herpes simplex virus. The author has an hindex of 11, co-authored 20 publications receiving 556 citations.
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Journal ArticleDOI
Local immune response to respiratory syncytial virus infection is diminished in senescence-accelerated mice.
Beixing Liu,Yoshinobu Kimura +1 more
TL;DR: It is suggested that age-related immune dysfunction, especially defects in cellular immune responses, accounts for the increased morbidity and mortality in RSV infection of the elderly.
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Iba1-expressing microglia respond to herpes simplex virus infection in the mouse trigeminal ganglion.
Isamu Mori,Fumi Goshima,Tetsuo Koshizuka,Yoshinori Imai,Shinichi Kohsaka,Naoki Koide,Tsuyoshi Sugiyama,Tomoaki Yoshida,Takashi Yokochi,Yoshinobu Kimura,Yukihiro Nishiyama +10 more
TL;DR: Collectively, Iba1-bearing microglia exist in the mouse trigeminal ganglion and respond to herpes simplex virus infection, most likely conferring neuroprotective functions upon the trigeminals ganglions.
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Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus.
Isamu Mori,Isamu Mori,Fumi Goshima,Tetsuro Koshizuka,Naoki Koide,Tsuyoshi Sugiyama,Tomoaki Yoshida,Takashi Yokochi,Yukihiro Nishiyama,Yoshinobu Kimura +9 more
TL;DR: Results indicate that these two stress-activated protein kinases may play distinct roles during the course of lethal acute influenza virus encephalitis.
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HF10, an attenuated herpes simplex virus (HSV) type 1 clone, lacks neuroinvasiveness and protects mice against lethal challenge with HSV types 1 and 2
Isamu Mori,Isamu Mori,Beixing Liu,Fumi Goshima,Hiroyasu Ito,Naoki Koide,Tomoaki Yoshida,Takashi Yokochi,Yoshinobu Kimura,Yukihiro Nishiyama +9 more
TL;DR: It is proposed that HF10 explicitly meets the prerequisites for a candidate live attenuated HSV vaccine, as it exhibits impaired neuroinvasiveness in peripheral olfactory, vomeronasal and trigeminal conduits following intranasal as well as corneal inoculation.
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The US3 protein kinase of herpes simplex virus attenuates the activation of the c-Jun N-terminal protein kinase signal transduction pathway in infected piriform cortex neurons of C57BL/6 mice.
Isamu Mori,Fumi Goshima,Tetsuo Koshizuka,Naoki Koide,Tsuyoshi Sugiyama,Tomoaki Yoshida,Takashi Yokochi,Yoshinobu Kimura,Yukihiro Nishiyama +8 more
TL;DR: Collectively, the US3 protein kinase of HSV plays a role in attenuating the virus-induced activation of the JNK signal transduction pathway in the central nervous system and may contribute, at least in part, to controlling neuronal apoptosis.