R
Ryuichi Fujisawa
Researcher at Hokkaido University
Publications - 45
Citations - 1900
Ryuichi Fujisawa is an academic researcher from Hokkaido University. The author has contributed to research in topics: Bone sialoprotein & Type I collagen. The author has an hindex of 21, co-authored 45 publications receiving 1827 citations.
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Type I collagen‐induced osteoblastic differentiation of bone‐marrow cells mediated by collagen‐α2β1 integrin interaction
TL;DR: It is shown that type I collagen matrix gels induce osteoblastic differentiation of bone marrow cells with high alkaline phosphatase activity, collagen synthesis, and formed mineralized tissues with anti‐α 2 integrin antibody, which interacts with α subunit of Integrin and blocks the binding of integrin with collagen.
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Acidic amino acid-rich sequences as binding sites of osteonectin to hydroxyapatite crystals.
TL;DR: Effects of these peptides on in vitro mineralization indicate the presence of an interaction between these peptide and mineral crystals.
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Selective drug delivery system to bone: small peptide (Asp)6 conjugation.
TL;DR: Conjugated (Asp)6 to fluorescein isothiocyanate (FITC) and evaluated its affinity to HA in vitro, and examined its tissue distribution after injection into rats indicate that (AsP)6 is effective as a carrier for selective drug delivery to bone.
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Preferential adsorption of dentin and bone acidic proteins on the (100) face of hydroxyapatite crystals
TL;DR: Adsorption of acidic non-collagenous proteins on hydroxyapatite was examined using fluorescence-labeled protein and synthetic hydroxyAPatite to find out what is responsible for the morphogenesis of biological hydroxyapsatite.
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Selective Delivery of Estradiol to Bone by Aspartic Acid Oligopeptide and Its Effects on Ovariectomized Mice
Koichi Yokogawa,Kazuhiro Miya,Tohru Sekido,Yasuhiko Higashi,Masaaki Nomura,Ryuichi Fujisawa,Keiko Morito,Yukito Masamune,Yoshihiro Waki,Shohei Kasugai,Ken-ichi Miyamoto +10 more
TL;DR: A novel osteotropic prodrug of estradiol conjugated with l-Asp-hexapeptide (E2·3D6), which has very low affinity for estrogen receptors, is developed and its pharmacokinetic behavior and pharmacological potential are examined.