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Youn H. Kim
Researcher at Stanford University
Publications - 308
Citations - 18932
Youn H. Kim is an academic researcher from Stanford University. The author has contributed to research in topics: Mycosis fungoides & Cutaneous T-cell lymphoma. The author has an hindex of 68, co-authored 289 publications receiving 16783 citations. Previous affiliations of Youn H. Kim include University of Washington & Harvard University.
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Journal ArticleDOI
Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).
Elise A. Olsen,Eric C. Vonderheid,Nicola Pimpinelli,Rein Willemze,Youn H. Kim,Robert Knobler,Herschel S. Zackheim,Madeleine Duvic,Teresa Estrach,Stanford I. Lamberg,Gary S. Wood,Reinhard Dummer,Annamari Ranki,Günter Burg,Peter Heald,Mark R. Pittelkow,M.G. Bernengo,Wolfram Sterry,Liliane Laroche,Franz Trautinger,Sean Whittaker +20 more
TL;DR: These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides and Sézary syndrome to clarify certain variables that currently impede effective interinstitution and interinvestigator communication and/or the development of standardized clinical trials in MF and SS.
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Phase IIB Multicenter Trial of Vorinostat in Patients With Persistent, Progressive, or Treatment Refractory Cutaneous T-Cell Lymphoma
Elise A. Olsen,Youn H. Kim,Timothy M. Kuzel,Theresa R. Pacheco,Francine M. Foss,Sareeta Parker,Stanley R. Frankel,Cong Chen,Justin L. Ricker,Jean Marie Arduino,Madeleine Duvic +10 more
TL;DR: Oral vorinostat was effective in treatment refractory MF/SS with an acceptable safety profile and time to response, time to progression, duration of response, and pruritus relief.
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Final Results From a Multicenter, International, Pivotal Study of Romidepsin in Refractory Cutaneous T-Cell Lymphoma
Sean Whittaker,Marie-France Demierre,Ellen J. Kim,Alain H. Rook,Adam Lerner,Madeleine Duvic,Julia Scarisbrick,Sunil Reddy,Tadeusz Robak,Jürgen C. Becker,Alexey Samtsov,William McCulloch,Youn H. Kim +12 more
TL;DR: Romidepsin has significant and sustainable single-agent activity (including improvement in pruritus) and an acceptable safety profile, making it an important therapeutic option for treatment refractory CTCL.
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Pivotal Phase III Trial of Two Dose Levels of Denileukin Diftitox for the Treatment of Cutaneous T-Cell Lymphoma
Elise A. Olsen,Madeleine Duvic,Arthur E. Frankel,Youn H. Kim,Ann Martin,Eric C. Vonderheid,Brian V. Jegasothy,Gary S. Wood,Michael S. Gordon,Peter W. Heald,Allan Oseroff,Lauren C. Pinter-Brown,Glen Bowen,Timothy M. Kuzel,David P. Fivenson,Francine M. Foss,Michael Glode,Arturo Molina,Elizabeth Knobler,Stanford J. Stewart,Kevin D. Cooper,Seth R. Stevens,Fiona E. Craig,James M. Reuben,Patricia Bacha,Jean Nichols +25 more
TL;DR: Denileukin diftitox has been shown to be a useful and important agent in the treatment of patients whose CTCL is persistent or recurrent despite other therapeutic interventions.
Journal ArticleDOI
Long-term Outcome of 525 Patients With Mycosis Fungoides and Sézary Syndrome: Clinical Prognostic Factors and Risk for Disease Progression
Abstract: Objectives To study and update the clinical characteristics and long-term outcome of our patients with mycosis fungoides (MF) and Sezary syndrome (SS), and to identify important clinical factors predictive of survival and disease progression. Design A single-center, retrospective cohort analysis. Setting Academic referral center for cutaneous lymphoma. Patients Five hundred twenty-five patients with MF and SS evaluated and managed at Stanford University Cutaneous Lymphoma Clinic, Stanford, Calif, from 1958 through 1999. Main Outcome Measures We calculated long-term actuarial overall and disease-specific survivals and disease progression by the Kaplan-Meier method, and relative risk (RR) for survival calculated from expected survivals in control populations. Results The majority of our patients presented with T1 (30%) or T2 (37%) disease; 18% presented with T3 and 15% with T4 skin involvement. Forty-three percent of deaths were attributable to MF, primarily in patients with T3 or T4 disease. The patients with a more advanced T classification and clinical stage had a worse survival outcome. Except for patients with T1 or stage IA disease, the RR for death is greater in patients with MF than in a control population (RR, 2.2 in stage IB/IIA disease, 3.9 in stage IIB/III disease, and 12.8 in stage IV disease). Despite similar overall survival in patients with stage IB or IIA disease, their disease-specific survivals were significantly different ( P = .006). The most significant clinical prognostic factors in the univariate analysis were patient age, TNM and B classifications, overall clinical stage groupings, and the presence or absence of extracutaneous disease. In the multivariate analysis, patient age, T classification, and the presence of extracutaneous disease were the most important independent factors. The risk for disease progression to a more advanced TNM or B classification, worse clinical stage, or death due to MF correlated with the severity of the initial T classification. The risk for development of extracutaneous disease also correlated with T classification; none of these patients had T1 disease when their extracutaneous disease was detected. Conclusions Patients with MF and SS have varying risks for disease progression or death. The most important clinical predictive factors for survival include patient age, T classification, and the presence of extracutaneous disease. The significant disease-specific survival differences between different clinical stages validate the usefulness of the present MF clinical staging system of the National Cancer Institute.