抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

Infectious Diseases Society of America.

https://www.medpagetoday.com/upload/2008/3/6/CRC.pdf

Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.

La presente invention concerne un nouveau derive de quinazoline et un sel de qualite pharmaceutique dudit derive, employes dans le but d’inhiber la croissance des cellules cancereuses, une methode de synthese dudit derive et de son sel et une preparation pharmaceutique comprenant ledit derive ou son sel au titre de principe actif.

Dérivés de quinazoline employés dans l'inhibition de la croissance des cellules cancéreuses et méthodes de synthèse desdits dérivés

Dérivés de quinazoline en tant qu'inhibiteurs multiplex et méthode de synthèse desdits dérivés

Communicating hydrocephalus following treatment of cerebellopontine angle tumors.

The objective of this study is to report the progression of congenital hyperlordoscoliosis in a 2-year-old patient and the use of multiple surgical interventions in the treatment of hyperlordoscoliosis of the thoracic spine. A 2-year-old patient with thoracic hyperlordosis underwent observation for 1 year. To halt the progression of hyperlordosis, a posterior laminectomy was carried out to remove all the fused segments. Despite surgery, lordosis progressed via spontaneous autofusion with development of scoliosis with unilateral unsegmented bar. At the age of 9 years, the patient underwent posterior osteotomy at the fused segments, which was unsuccessful in the correction of hyperlordosis, but was successful in the correction of scoliosis. At the age of 12 years, the patient complained of mild breathing difficulties resulting from hyperlordosis of the thoracic spine, and underwent posterior multilevel vertebral osteotomy (PMVO) again to correct lordoscoliosis. Follow-up in the 3 years after PMVO showed that correction of the deformity was well maintained, with a good clinical outcome and a well-balanced spine. PMVO is a potential intervention to manage rigid and severe congenital lordoscoliosis of the thoracic spine.

Long-term management of congenital lordoscoliosis of the thoracic spine

https://pubs.rsna.org/doi/pdf/10.1148/radiol.13130399?ai=s0&ui=qz6&af=H

Young Hoon Kim

Papers

Dérivés de quinazoline employés dans l'inhibition de la croissance des cellules cancéreuses et méthodes de synthèse desdits dérivés

Dérivés de quinazoline en tant qu'inhibiteurs multiplex et méthode de synthèse desdits dérivés

Communicating hydrocephalus following treatment of cerebellopontine angle tumors.

Long-term management of congenital lordoscoliosis of the thoracic spine

Osteoporotic and Malignant compression Fractures of the s pine: Use of Additive Qualitative and