抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

Infectious Diseases Society of America.

https://www.medpagetoday.com/upload/2008/3/6/CRC.pdf

Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.

WITHDRAWN: HM47118A, a novel insulinotropic GPR119 agonist and potential oral antidiabetic agent.

Background:Coronary spasm can be induced by acetylcholine(ACh). ACh causes vasodilation when the endothelium is intact by releasing nitric oxide(NO). The aim of this study was to investigate whether L-arginine, the precursor of NO, could preserve endothelium-dependent vasodilation in patients with coronary artery spasm. Methods:NO precusor L-arginine(20mg/kg/min) was infused intravenously for 30 minutes in nineteen patients with coronary spastic angina. Coronary spasm of the epicardial coronary artery (>75%) was induced by intracoronary injection of acetylcholine in incremental doses(ACh:A1 20ug, A2 50ug, A3 100ug);the spasm was then documented angiographically in all patients with coronary spastic angina. After the administration of L-arginine, intracoronary injection of acetylcholine was repeated as the same method in all coronary spastic angina patients. Results:After systemic infusion of L-arginine, the constrictor response to ACh was significanfly attenuated:no spastic response in 8 cases(42%), increased doses of ACh for provoking spasm in 8 cases(42%), and no change in 3 cases(16%). There were no significant changes in blood pressure and heart rate after the administration of L-arginine. Conclusion:The fact that L-arginine attenuated vasospasm, provoked by ACh in human coronary arteries, suggests the possibility that L-arginine may be used in the prevention and treatment of coronary spasm.

/pdf/effects-of-l-arginine-on-coronary-artery-spasm-induced-by-16xoksgtai.pdf

Effects of L-Arginine on Coronary Artery Spasm Induced by Intracoronary Acetylcholine in Patients with Angina Pectoris with Normal Coronary Angiogram

The present invention relates to a light-emitting device comprising a perovskite-organic small molecule host mixed light-emitting layer and a method for manufacturing same. According to the present invention, it is possible to adjust an energy level, a charge transport rate, and a light-emission wavelength of the perovskite-organic small molecule host mixed light-emitting layer in the light-emitting device according to a material type, a ratio between materials, and a deposition rate by using a deposition method. In addition, there is an advantage of it being possible to improve electroluminescence efficiency by controlling an electron-hole recombination zone of the light-emitting device through same. Moreover, there is an advantage of it being possible to reduce the size of a perovskite crystal formed by co-depositing an organic small molecule host with a metal halide perovskite.

Light-emitting device comprising perovskite-organic small molecule host mixed light-emitting layer and method of manufacturing same

Isolated double chambers of the right ventricle (DCRV) are a rare variant of congenital heart disease. We report here on a case of right-sided infective endocarditis with isolated DCRV that presented in adulthood. (Korean Circulation J 2007;37:180-182)

Young Hoon Kim

Papers

WITHDRAWN: HM47118A, a novel insulinotropic GPR119 agonist and potential oral antidiabetic agent.

Effects of L-Arginine on Coronary Artery Spasm Induced by Intracoronary Acetylcholine in Patients with Angina Pectoris with Normal Coronary Angiogram

Light-emitting device comprising perovskite-organic small molecule host mixed light-emitting layer and method of manufacturing same

Infective Endocarditis with Isolated Double Chambers of the Right Ventricle during Adulthood

Intrathecal drug delivery to treat intractable neuropathic pain following Sjögren's syndrome-induced transverse myelitis: A case report.