Showing papers by "Yu-ichi Noto published in 2010"
TL;DR: In patients with neuropathy, nodal persistent Na(+) currents in large sensory fibers increase, and the abnormal currents can be suppressed by mexiletine, raising the possibility that excessive Na(+ currents are also suppressed in small fibers mediating neuropathic pain.
23 citations
TL;DR: Three patients with sarcoidosis who presented with multiple mononeuropathy who showed prominent multifocal conduction blocks in the intermediate nerve trunk are reported, and electrodiagnostic findings suggest that demyelinative or ischemic-functional conduction block is responsible for their neuropathy.
Abstract: Peripheral neuropathy is a rare manifestation of sarcoidosis, and previous studies have shown axonal degeneration as the main pathology. We herein report three patients with sarcoidosis who presented with multiple mononeuropathy as the initial manifestation. Nerve conduction studies showed prominent multifocal conduction blocks in the intermediate nerve trunk. In all three patients, corticosteroid treatment resulted in a dramatic clinical improvement associated with rapid resolution of conduction blocks. The sequential electrodiagnostic findings suggest that demyelinative or ischemic-functional conduction block is responsible for their neuropathy. To date, only three cases of acute conduction block neuropathy associated with sarcoidosis have been reported, but it may occur more frequently than expected.
7 citations
TL;DR: In this article, a wide range of ALS patients with using MUNE technique in bilateral hand muscles were surveyed, and the authors identified that disease severity and progression in ALS are asymmetrical in bilateral sides, and less affected side catches up the more affected side over time.
1 citations
TL;DR: Clinically, polyneuropathy patients more frequently complain of paresthesia/dysesthesia in the hairless palm than in the hairy dorsal hand, and this study investigated differences in excitability properties between human median and superficial radial axons innervating the hand.
1 citations