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Shunsuke Koga
Researcher at Mayo Clinic
Publications - 118
Citations - 2658
Shunsuke Koga is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Progressive supranuclear palsy. The author has an hindex of 24, co-authored 77 publications receiving 1793 citations. Previous affiliations of Shunsuke Koga include Chiba University & University of Pennsylvania.
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Journal ArticleDOI
When DLB, PD, and PSP masquerade as MSA An autopsy study of 134 patients
Shunsuke Koga,Naoya Aoki,Ryan J. Uitti,Jay A. van Gerpen,William P. Cheshire,Keith A. Josephs,Zbigniew K. Wszolek,J. William Langston,Dennis W. Dickson +8 more
TL;DR: The diagnostic accuracy for MSA was suboptimal in this autopsy study, and pathologically confirmed DLB, PD, and PSP were the most common diseases to masquerade as MSA.
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Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
Maiko Ono,Maiko Ono,Naruhiko Sahara,Katsushi Kumata,Bin Ji,Ruiqing Ni,Shunsuke Koga,Dennis W. Dickson,John Q. Trojanowski,Virginia M.-Y. Lee,Mari Yoshida,Isao Hozumi,Yasumasa Yoshiyama,John C. van Swieten,Agneta Nordberg,Tetsuya Suhara,Ming-Rong Zhang,Makoto Higuchi +17 more
TL;DR: Compared binding of tau positron emission tomography ligands, PBB3 and AV-1451, by fluorescence, autoradiography and homogenate binding assays with homologous and heterologous blockades using tauopathy brain samples indicate distinct selectivity of P BB3 compared to AV- 1451 for diverse tau fibril strains.
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Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy
Saiko Nasu,Sonoko Misawa,Yukari Sekiguchi,Kazumoto Shibuya,Kazuaki Kanai,Yumi Fujimaki,Shigeki Ohmori,Satsuki Mitsuma,Shunsuke Koga,Satoshi Kuwabara +9 more
TL;DR: Before development of typical systemic manifestations, POEMS neuropathy can be distinguished from CIDP by the clinical profile and patterns of nerve conduction abnormalities.
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Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis
Kazuaki Kanai,Kazumoto Shibuya,Yasunori Sato,Sonoko Misawa,Saiko Nasu,Yukari Sekiguchi,Satsuki Mitsuma,Sagiri Isose,Yumi Fujimaki,Shigeki Ohmori,Shunsuke Koga,Satoshi Kuwabara +11 more
TL;DR: Axonal persistent sodium currents, estimated by strength–duration time constant and latent addition, are strong and independent predictors for shorter survival in patients with ALS.
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APOE ε2 is associated with increased tau pathology in primary tauopathy.
Na Zhao,Chia Chen Liu,Alexandra J. Van Ingelgom,Cynthia Linares,Aishe Kurti,Joshua Knight,Michael G. Heckman,Nancy N. Diehl,Mitsuru Shinohara,Yuka A. Martens,Olivia N. Attrebi,Leonard Petrucelli,John D. Fryer,Zbigniew K. Wszolek,Neill R. Graff-Radford,Richard J. Caselli,Monica Sanchez-Contreras,Rosa Rademakers,Melissa E. Murray,Shunsuke Koga,Dennis W. Dickson,Owen A. Ross,Guojun Bu +22 more
TL;DR: It is shown that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits and that the APOEε2 allele is associated with an increased burden of t Tau pathology in postmortem human brains with progressive supranuclear palsy.