Yu Xu

TL;DR: Wang et al. as mentioned in this paper analyzed the clinical characteristics, outcomes, and risk factors affecting the prognosis of Parkinson's disease patients with severe COVID-19 infection, and found that patients with critical type, disturbance of consciousness, incidence of complications, white blood cells count and neutrophils counts on admission seem higher in the non-survivors.

TL;DR: In this article , the authors investigated differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson's disease (PD) and healthy controls (HCs) and found that reduced functional connectivity were mainly observed in the visual (VSN), somatomotor (SMN), limbic (LBN), and deep gray matter networks (DGN) at integrity level.

TL;DR: In this paper, the authors investigated macroscopic structural changes in a rat model of Parkinson's disease and the underlying histological mechanisms and found that the structural changes were partially reversed by chronic L-DOPA administration; moreover, a significant volume increase mainly in the dorsolateral striatum, substantia nigra and piriform cortex of the lesioned side compared with that of PD rats.

TL;DR: In this article , a rat model of Parkinson's disease characterized by widespread, seed-initiated endogenous α-synuclein pathology, impaired axonal transport, and a neurodegenerative cascade in the nigrostriatal system was presented.

TL;DR: Induced endogenous α-synuclein can quickly propagate into the proximal colon mainly via the vagus nerve, and injections of low doses of preformed fibrils can elicit recovery of the enteric nervous system and degradation of α- Synuclein aggregates whereas high doses cause accumulation of pathological α- synuclein, enteric inflammation, and prominent gastrointestinal dysfunction.