Y
Yu Yamaguchi
Researcher at Nagasaki University
Publications - 12
Citations - 212
Yu Yamaguchi is an academic researcher from Nagasaki University. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 6, co-authored 12 publications receiving 152 citations.
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Journal ArticleDOI
Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes.
Eiko Sakai,Megumi Shimada-Sugawara,Yu Yamaguchi,Hiroshi Sakamoto,Reiko Fumimoto,Yutaka Fukuma,Kazuhisa Nishishita,Kuniaki Okamoto,Takayuki Tsukuba +8 more
TL;DR: Effects of fisetin, a natural bioactive flavonoid that has been reported to induce HO-1 expression, on the differentiation of macrophages into OCLs are investigated and it is demonstrated that regulation of heme-oxygenase 1 (HO-1) also functions in OCL differentiation.
Journal ArticleDOI
Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation.
Yu Yamaguchi,Eiko Sakai,Kuniaki Okamoto,Hiroshi Kajiya,Koji Okabe,Mariko Naito,Tomoko Kadowaki,Takayuki Tsukuba +7 more
TL;DR: Results suggest that Rab44 negatively regulates osteoclast differentiation by modulating intracellular Ca2+ levels followed by NFATc1 activation, which affects nuclear factor of activated T-cells c1 signaling in RANKL-stimulated macrophages.
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The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation
Reiko Fumimoto,Eiko Sakai,Yu Yamaguchi,Hiroshi Sakamoto,Yutaka Fukuma,Kazuhisa Nishishita,Kuniaki Okamoto,Takayuki Tsukuba +7 more
TL;DR: It is shown that kahweol in coffee is a useful constituent for inhibition of OCL differentiation and up-regulated heme oxygenase-1 and inhibited high mobility group box 1 release.
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Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenase-1 and NFATc1.
Hiroshi Sakamoto,Eiko Sakai,Reiko Fumimoto,Yu Yamaguchi,Yutaka Fukuma,Kazuhisa Nishishita,Kuniaki Okamoto,Takayuki Tsukuba +7 more
TL;DR: It is shown that deltamethrin inhibited OCL differentiation in vitro and possibly affects bone metabolism by inhibition of nuclear factor kappa B alpha (IκBα) compared with untreated OCLs.
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Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression.
Yu Yamaguchi,Eiko Sakai,Hiroshi Sakamoto,Reiko Fumimoto,Yutaka Fukuma,Kazuhisa Nishishita,Kuniaki Okamoto,Takayuki Tsukuba +7 more
TL;DR: This study investigated the effects of tert‐butylhydroquinone (tBHQ), a pharmacological HO‐1 inducer, on in vitro differentiation of bone marrow‐derived macrophages or murine monocytic cell line RAW‐D into OCLs and inhibited the release of high mobility group box 1 (HMGB1), a recently identified activator of OCL differentiation.