Yu-Yan Tan

TL;DR: The results indicated that the methylation level of SNCA CpG-2, especially that of the 2nd, 4th and 9th C pG sites in leukocytes might have great potential to be a useful and informative biomarker in PD diagnosis and treatment.

TL;DR: The experiments demonstrated that curcumin can prevent nigrostriatal degeneration by inhibiting the dysfunction of mitochondrial through suppressing hyperphosphorylation of JNKs induced by MPTP, and suggested that JNK/mitochondria pathway may be a novel target in the treatment of PD patients.

TL;DR: It is shown that Abeta1-42 triggered autophagic cell death in both human glioma cell line (U87 cell) and human neuroblastoma cell lines (SH-SY5Y cell), which provides further insights into the mechanisms underlying Abeta-induced cytotoxicity.

TL;DR: Several risk factors of FOG have been identified, but need combinatorial optimization for predicting FOG more precisely and firm conclusions cannot be drawn on therapeutic efficacy, although the literature suggested that some therapeutic strategies showed promise.

TL;DR: Total cost was significantly associated with the disease severity and the frequency of outpatient visits, and levodopa equivalent dose and the number of drugs being taken were also closely related with the drug cost.