Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby's skin. The behavior of some cells on soft materials is characteristic of important phenotypes; for example, cell growth on soft agar gels is used to identify cancer cells. However, an understanding of how tissue cells-including fibroblasts, myocytes, neurons, and other cell types-sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels (or to other cells) with which elasticity can be tuned to approximate that of tissues. Key roles in molecular pathways are played by adhesion complexes and the actinmyosin cytoskeleton, whose contractile forces are transmitted through transcellular structures. The feedback of local matrix stiffness on cell state likely has important implications for development, differentiation, disease, and regeneration.

/pdf/tissue-cells-feel-and-respond-to-the-stiffness-of-their-6dx0rumap6.pdf

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI

http://mech.spbstu.ru/images/b/bd/Potyondy_Cundall_2004_A_bonded-particle_model_for_rock.pdf

A bonded-particle model for rock

A balanced mechanics-materials approach and coverage of the latest developments in biomaterials and electronic materials, the new edition of this popular text is the most thorough and modern book available for upper-level undergraduate courses on the mechanical behavior of materials To ensure that the student gains a thorough understanding the authors present the fundamental mechanisms that operate at micro- and nano-meter level across a wide-range of materials, in a way that is mathematically simple and requires no extensive knowledge of materials This integrated approach provides a conceptual presentation that shows how the microstructure of a material controls its mechanical behavior, and this is reinforced through extensive use of micrographs and illustrations New worked examples and exercises help the student test their understanding Further resources for this title, including lecture slides of select illustrations and solutions for exercises, are available online at wwwcambridgeorg/97800521866758

/pdf/mechanical-behavior-of-materials-244bo22qlo.pdf

Mechanical Behavior of Materials

Mechanical stresses were applied directly to cell surface receptors with a magnetic twisting device. The extracellular matrix receptor, integrin beta 1, induced focal adhesion formation and supported a force-dependent stiffening response, whereas nonadhesion receptors did not. The cytoskeletal stiffness (ratio of stress to strain) increased in direct proportion to the applied stress and required intact microtubules and intermediate filaments as well as microfilaments. Tensegrity models that incorporate mechanically interdependent struts and strings that reorient globally in response to a localized stress mimicked this response. These results suggest that integrins act as mechanoreceptors and transmit mechanical signals to the cytoskeleton. Mechanotransduction, in turn, may be mediated simultaneously at multiple locations inside the cell through force-induced rearrangements within a tensionally integrated cytoskeleton.

https://science.sciencemag.org/content/sci/260/5111/1124.full.pdf

Mechanotransduction across the cell surface and through the cytoskeleton

Prefaces. 1. Introduction: A sketch of the History and Scope of the Field. 2. The Meaning of the Constitutive Equation. 3. The Flow Properties of Blood. 4. Mechanics of Erythrocytes, Leukocytes, and Other Cells. 5. Interaction of Red Blood Cells with Vessel Wall, and Wall Shear with Endothelium. 6 Bioviscoelastic Fluids. Bioviscoelastic Solids. 8. Mechanical Properties and Active Remodeling of Blood Vessels. 9. Skeletal Muscle. 10. Heart Muscle. 11. Smooth Muscles. 12. Bone and Cartilage. Indices

Biomechanics: Mechanical Properties of Living Tissues

/pdf/biomechanics-mechanical-properties-of-living-tissues-15c591ao7g.pdf

Foundations of solid mechanics

An introduction to the theory of aeroelasticity , An introduction to the theory of aeroelasticity , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی

An introduction to the theory of aeroelasticity

1. Physiological introduction 2. Propagation of the pressure pulse 3. Flow patterns and wall shear stress in arteries I Straight tubes 4. Flow patterns and wall shear stress in arteries II. Curved tubes 5. Flow patterns and wall shear stress in arteries III. Branched tubes and flow instability 6. Flow in collapsible tubes.

Yuan-Cheng Fung

Papers

Biomechanics: Mechanical Properties of Living Tissues

Biomechanics: Mechanical Properties of Living Tissues

Foundations of solid mechanics

An introduction to the theory of aeroelasticity

The fluid mechanics of large blood vessels