Yuan Jiang

TL;DR: Gene expression profiling identified human melanoma cells demonstrating increased cell motility and invasiveness and blocked this pathway using antibodies to Frizzled-5, the receptor for Wnt5a, inhibited PKC activity and cellular invasion.

TL;DR: The use of cDNA microarrays containing 1238 cDNAs to investigate the gene expression profile of a group of seven alveolar rhabdomyosarcoma (ARMS) cell lines determined that ARMS cells show a consistent pattern of gene expression, which allows the cells to be clustered together.

TL;DR: RWnt5A treatment increases Snail and vimentin expression, and decreases E-cadherin, even in the presence of dominant-negativeTCF4, suggesting that this activation is independent of Wnt/β-catenin signaling.

TL;DR: This is the first application of the microarray technique to study hormonal regulation of gene expression in vivo and should prove to be a powerful tool for future studies of hormone and drug action.

TL;DR: DNA copy number profiles were generated by CGH for most of the publicly available breast cancer cell lines and were made available on a web site and should facilitate the correlative analysis of gene expression and copy number as illustrated here by the finding by cDNA microarrays of several overexpressed genes that were amplified.