Showing papers by "Yuan Li published in 2022"

[Trends of overweight and obesity among children and adolescents aged 7-17 in 16 provinces of China from 2000 to 2018].

Abstract: OBJECTIVE To analyze the distribution characteristics and trends of overweight and obesity in children and adolescents aged 7-17 years in 16 provinces of China. METHODS Data were collected from China health and nutrition survey in 2000, 2006, 2011, 2015 and 2018, 8398 children and adolescents aged 7-17 with complete data were selected as the research objects. Overweight and obesity were classified by body mass index(BMI) reference norm for screening overweight and obesity in Chinese children and adolescents. The distribution and trend of overweight and obesity among children and adolescents aged 7-17 in 16 provinces of China were analyzed by using Cochran-Armitage trend test and two-level random intercept model. RESULTS The prevalence of overweight and obesity in children and adolescents aged 7-17 in China showed an upward trend from 2000 to 2018(P<0.05). The prevalence of overweight increased from 5.42% in 2000 to 12.92% in 2018, and the prevalence of obesity increased from 2.45% in 2000 to 12.36% in 2018. The result of multilevel model analysis showed that gender and urban and rural areas had significant effects on centralized BMI(P<0.05), the BMI increase value of boys was greater than that of girls(β=0.2824), the BMI increase value of children and adolescents in rural areas was greater than that in urban areas(β=0.5902). CONCLUSION The prevalence of overweight and obesity among children and adolescents aged 7-17 in 16 provinces of China are increasing.

[Multilevel study on the effects of dietary nutrients on body mass index of Chinese children and adolescents aged 7-17].

Abstract: OBJECTIVE Analyze the relationship between dietary nutrients and body mass index of children and adolescents aged 7-17 in China. METHODS The data comes from the "China Health and Nutrition Survey", and 5562 children and adolescents aged 7-17 who participated in at least one round(2000, 2006, 2011 and 2015) of the survey and had complete dietary and physical measurement survey data were selected as the research objects. A three-level(community-individual-observation level) linear random intercept mixed effect model of body mass index was constructed to analyze the influence of dietary nutrient intake of children and adolescents of different genders in urban and rural areas on their body mass index(BMI).24 hours for 3 consecutive days and family weight accounting were used to evaluate the dietary nutrient intake. RESULTS BMI of urban children and adolescents is higher than that of rural children and adolescents. The BMI of children and adolescents aged 12-17 is higher than that of children and adolescents aged 7-11. BMI of boys was higher than that of girls, but the difference was statistically significant only in 2011 and 2015. After controlling for confounding factors such as individual level(survey year, age, physical activity and family per capita income) and community level(community urbanization index), the three-level model showed that the BMI of rural boys increased with the increase of cholesterol intake(P<0.01). BMI of urban girls increased with the increase of vitamin B_1 intake(P<0.05) and iron intake(P<0.01). BMI of rural girls increased with the increase of vitamin E intake(P<0.001) and sodium intake(P<0.05). CONCLUSION There are some differences in dietary nutrients that affect the BMI level of 7-17 years old children and adolescents between urban and rural areas.

Platelet Membrane Cloaked Nanotubes to Accelerate Thrombolysis by Thrombus Clot-Targeting and Penetration.

Abstract: Thrombotic diseases have a high rate of mortality and disability, and pose a serious threat to global public health. Currently, most thrombolytic drugs especially protein drugs have a short blood-circulation time, resulting in low thrombolytic efficiency. Therefore, a platelet membrane (Pm) cloaked nanotube (NT-RGD/Pm) biomimetic delivery system with enhanced thrombolytic efficiency is designed. Nanotubes (NT) with an excellent clot-penetration properties are used to load a protein thrombolytic drug urokinase (Uk). Platelet-targeting arginine glycine-aspartic peptide (RGD) is grafted onto the surface of the nanotubes (NT-RGD) prior to cloaking. Multiple particle tracking (MPT) technique and confocal laser scanning microscope (CLSM) analysis are applied and the results show that the nanotubes possess a strong penetration and diffusion capacity in thrombus clots. After the Pm cloaking on NT-RGD/Uk, it shows a thrombus microenvironmental responsive release property and the half-life of Uk is six times longer than that of free Uk. Most importantly, NT-RGD-Uk/Pm exhibits a 60% thrombolytic efficiency in the FeCl3 -induced thrombosis mouse model, and it is able to significantly reduce the bleeding side effects of Uk. This Pm-cloaked nanotube system is an effective and promising platform for the controlled and targeted delivery of drugs for the thrombus treatment.

Influence of SCENIC recommendations on terminology used for histopathologic diagnosis of inflammatory bowel disease-associated dysplasia

Abstract: BACKGROUND Published in 2015, the International Consensus Recommendations on Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients (SCENIC) recommended abandoning the use of diagnostic term “dysplasia-associated lesion or mass (DALM)” for polypoid dysplastic lesions detected in patients with inflammatory bowel disease (IBD). The aim of this study was to investigate whether this recommendation had any influence on diagnostic terminologies used by pathologists in their practice. METHODS We retrospectively reviewed all pathology reports for surveillance colonoscopic biopsies from ulcerative colitis (UC) patients in our institution during 1/2012-12/2014 (pre-SCENIC) and 1/2016-12/2018 (post-SCENIC). These included 1203 biopsies from 901 UC patients during the pre-SCENIC period and 1273 biopsies from 977 UC patients during the post-SCENIC period. Their corresponding endoscopic findings and histopathologic diagnoses were recorded. Clinical indications for total colectomy for UC patients and corresponding histopathologic findings in colectomy specimens were also recorded and compared. RESULTS A total of 347 and 419 polyps/polypoid lesions were identified during the pre-SCENIC and post-SCENIC periods, among which 60 and 104 were dysplastic/adenomatous, respectively. More polypoid dysplastic lesions were simply diagnosed as “adenoma” during the post-SCENIC period in comparison with the pre-SCENIC period (97.1% vs 65.0%; P < 0.001). The number of cases with a comment in pathology reports regarding the distinction between DALM and sporadic adenoma was also significantly decreased during the post-SCENIC period (5.8% vs 38.3%; P < 0.001). In addition, the term “dysplasia” was more consistently used for random biopsies during the post-SCENIC period. Furthermore, the terms “sessile serrated adenoma/polyp” (SSA/P) and “serrated epithelial change” (SEC) were more consistently used for polypoid lesions and random biopsies, respectively, during the post-SCENIC period, although these were not specifically addressed in the SCENIC recommendations. The indications for colectomy remained unchanged, however, despite the standardization of diagnostic terminologies. CONCLUSION The SCENIC recommendations relieve pathologists from the burden of distinguishing DALM from sporadic adenoma in IBD patients, which helps the standardization of diagnostic terminologies used by pathologists. The consistent use of the diagnostic terminologies may help reduce potential confusions to clinicians and patients.

Influence of detection noise on the maximum likelihood estimation of atmospheric turbulence fading parameters.

Abstract: Free space optical system design and performance analysis are highly related to channel statistics obtained by the channel parameter estimation. The accurate estimation of the channel parameters and scintillation index needs to consider the photoelectric detection noise at the receiving end. We propose a maximum likelihood (ML) method for estimating the parameters of a gamma-gamma fading channel affected by photoelectric detection noise. The Newton-Raphson method and expectation maximization (EM) algorithm are developed to compute the ML estimates of atmospheric turbulence fading parameters and variance of the detection noise. We also derive the Cramer-Rao bound for the unknown parameters. By way of the mean square estimation errors, our estimation technique performance is compared with existing methods of the estimation which ignore detection noise. Based on the measured channel and detection noise data under three weather conditions, it is verified that the proposed EM algorithm, considering the influence of detection noise, can significantly improve the estimation accuracy of atmospheric turbulence fading parameters.