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Yuan-Yuan Mao
Researcher at Zhejiang University
Publications - 5
Citations - 272
Yuan-Yuan Mao is an academic researcher from Zhejiang University. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Autophagy. The author has an hindex of 4, co-authored 5 publications receiving 203 citations.
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Journal ArticleDOI
Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury.
Yue Hu,Jian Lou,Yuan-Yuan Mao,Tianwen Lai,Li-Yao Liu,Chen Zhu,Chao Zhang,Juan Liu,Yu-Yan Li,Fan Zhang,Wen Li,Songmin Ying,Zhihua Chen,Huahao Shen +13 more
TL;DR: Results demonstrate that activation of MTOR in the epithelium promotes LPS-induced ALI, likely through downregulation of autophagy and the subsequent activation of NFKB, and may represent a novel therapeutic strategy for preventing ALI induced by certain bacteria.
Journal ArticleDOI
Bcl-2 Inhibitors Reduce Steroid-insensitive Airway Inflammation.
Bao-ping Tian,Lixia Xia,Zhengqiang Bao,Hao Zhang,Zhiwei Xu,Yuan-Yuan Mao,Chao Cao,Luanqing Che,J. X. Liu,Wen Li,Zhihua Chen,Songmin Ying,Huahao Shen,Huahao Shen +13 more
TL;DR: These inhibitors were found to be more efficient than steroids to induce granulocyte apoptosis ex vivo from patients with severe asthma, especially for corticosteroid‐insensitive neutrophilic airway inflammation.
Journal ArticleDOI
mTOR and autophagy in regulation of acute lung injury: a review and perspective
TL;DR: The mammalian target of rapamycin (mTOR) is a central regulator of many major cellular processes including protein and lipid synthesis and autophagy, and is also implicated in an increasing number of pathological conditions.
Journal ArticleDOI
mTOR complexes differentially orchestrates eosinophil development in allergy.
Chen Zhu,Lixia Xia,Fei Li,Lingren Zhou,Qingyu Weng,Zhou-Yang Li,Yinfang Wu,Yuan-Yuan Mao,Chao Zhang,Yanping Wu,Miao Li,Songmin Ying,Zhi-Hua Chen,Huahao Shen,Wen Li +14 more
TL;DR: The data uncovered the differential effects of mTOR in the regulation of eosinophil development, likely due to the distinct functions of m TOR complex 1 or 2, which thus exerts a pivotal implication in eos inophil-associated diseases.
Proceedings ArticleDOI
LATE-BREAKING ABSTRACT: Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury
Yue Hu,Lou Jian,Yuan-Yuan Mao,Tianwen Lai,Li-Yao Liu,Chen Zhu,Chao Zhang,Liu Juan,Wen Li,Songmin Ying,Zhihua Chen,Huahao Shen +11 more
TL;DR: Results demonstrate that activation of MTOR in the epithelium promotes LPS-induced ALI, likely through down-regulation of autophagy and its subsequent activation of NFKB, and may represent a novel therapeutic strategy for preventing ALI induced by certain bacteria.