[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

SPAdes, a new genome assembly algorithm and its applications to single-cell sequencing ( 7th Annual SFAF Meeting, 2012)

Open Innovation: The New Imperative for Creating and Profiting from Technology

Hypertension 66 (20.3%) 24 (24.2%) 30 (16.3%) NS Diabetes 20 (6.2%) 7 (7.1%) 10 (5.4%) NS Excess weight 78 (24%) 27 (27.3%) 44 (23.9%) NS Smokers 64 (19.7%) 17 (17.2%) 35 (19.0%) NS Age >50 years 137 (42.2%) 54 (54.5%) 67 (36.4%) <0.02 Kidney disease 7 (2.2%) 1 (1%) 5 (2.7%) NS Family history, DM 102 (31.4%) 28 (28.3%) 66 (35.9%) NS

Conflict of interest statement. None declared.

This presentation is a case study taken from the travel and holiday industry. Paxport/Multicom, based in UK and Sweden, have recently adopted a recommendation system for holiday accommodation bookings. Machine learning techniques such as Collaborative Filtering have been applied using Python (3.5.1), with Jupyter (4.0.6) as the main framework. Data scale and sparsity present significant challenges in the case study, and so the effectiveness of various techniques are described as well as the performance of Python-based libraries such as Python Data Analysis Library (Pandas), and Scikit-learn (built on NumPy, SciPy and matplotlib). The presentation is suitable for all levels of programmers.

Machine learning with Python

https://par.nsf.gov/servlets/purl/10079108

Lump solutions to nonlinear partial differential equations via Hirota bilinear forms

Lump solutions are analytical rational function solutions localized in all directions in space. We analyze a class of lump solutions, generated from quadratic functions, to nonlinear partial differential equations. The basis of success is the Hirota bilinear formulation and the primary object is the class of positive multivariate quadratic functions. A complete determination of quadratic functions positive in space and time is given, and positive quadratic functions are characterized as sums of squares of linear functions. Necessary and sufficient conditions for positive quadratic functions to solve Hirota bilinear equations are presented, and such polynomial solutions yield lump solutions to nonlinear partial differential equations under the dependent variable transformations u=2(ln f)_x and u=2(ln f)_{xx}, where x is one spatial variable. Applications are made for a few generalized KP and BKP equations.

An asynchronous position measurement system is proposed for indoor localization in this paper. The demonstrated system consists of a UWB transmitter and several energy detection receivers whose positions are known. The position measurement process starts with the locator emitting a UWB pulse. Upon arrival, the pulse is amplified and retransmitted by the target to be located. Signals from both the locator and the target are captured by the receivers. No synchronization mechanism is implemented. Instead, the proposed system measures the differential TOA between the direct coupling signal of the locator and the target signal. Together with the knowledge of the locator transmitter and receiver positions, the absolute range that the pulse travels can be calculated. The sum of transmitter-target range and target-receiver range defines an ellipse and the target resides on the intersections of several such ellipses. It is shown via the Cramer-Rao lower bound that the absolute-range-based elliptical localization is potentially more accurate than the relative-range-based hyperbolic localization. Our proposed system is able to achieve positioning error bound comparable to synchronous absolute-range-based localization systems while eliminating the cost of synchronization.

Indoor Elliptical Localization Based on Asynchronous UWB Range Measurement

Lump-type solutions, rationally localized in many directions in the space, are analyzed for nonlinear differential equations derived from generalized bilinear differential equations. By symbolic computations with Maple, positive quadratic and quartic polynomial solutions to two classes of generalized bilinear differential equations on f are computed, and thus, lump-type solutions are presented to the corresponding nonlinear differential equations on u, generated from taking a transformation of dependent variables u = 2(ln f)x.

Yuan Zhou

Papers

Lump solutions to nonlinear partial differential equations via Hirota bilinear forms

Lump solutions to nonlinear partial differential equations via Hirota bilinear forms

Indoor Elliptical Localization Based on Asynchronous UWB Range Measurement

Lump-type solutions to nonlinear differential equations derived from generalized bilinear equations

Pointwise characterizations of Besov and Triebel–Lizorkin spaces and quasiconformal mappings