Yuanyu Liao

TL;DR: The results suggested that DHA might repress esophageal cancer glycolysis partly by down-regulating PKM2 expression, and it is believed thatDHA might be a prospective agent against esophagal cancer.

TL;DR: It is demonstrated that PDT drives the Warburg effect in a time-dependent manner, and pyruvate kinase M2 plays an important role in this progress, which indicated that PKM2 may be a potential molecular target to increase the sensitivity of esophageal cancer cells to PDT.

TL;DR: In this article , the authors found that HOXB9 mRNA and protein levels are downregulated in pancreatic cancer tissues and cell lines, and they also found that over-expression of HOXb9 inhibits pancreatic cells cell proliferation both in cell lines and in mouse xenograft as well as PDX models.

TL;DR: Zhang et al. as discussed by the authors revealed that MARVELD1 acts as a mediator of DDR to perform early events and maintain genome stability, and showed that PARP1 PARylates MARVELd1 at D102, D118 and D130, and in turn, MARveld1 stabilizes PARP 1 by enhancing NAA50-mediated acetylation, thus forming a positive feedback loop.

TL;DR: In this article , the densities of CD8+ and FOXP3+ T cells in the tumor and invasive margin were processed by immunohistochemistry and digital pathology to form a scoring system named regulatory-Immunoscore (RIS).