Showing papers in "European Journal of Pharmacology in 2019"

TL;DR: Based on the literature survey compiled in this review, alkaloids represent an important group of anticancer drugs of plant origin with enormous potential for future development of drugs for cancer therapy and management.

TL;DR: The role of stem cells in skin wound healing acceleration is discussed and possible new strategies of stem cell application in treatment of chronic wounds are analysed.

TL;DR: It is demonstrated that MSC‐Exo ameliorated IRI in vivo or H/R induced apoptosis in vitro by inhibiting both intrinsic and extrinsic apoptosis pathway via miR‐21‐5p targeting PTEN and PDCD4, while artificial overexpressing PTEN orPDCD4 significantly attenuated the anti‐apoptotic effect of MSC­Exo in vitro.

TL;DR: The role of HMGB1 in the innate inflammatory response is highlighted, describing its interaction with several cofactors and receptors that coordinate its downstream effects.

TL;DR: It is reported that some pro‐inflammatory cytokines inducing migraine may be inhibited by IL‐37, a natural suppressor of inflammation, and innate and acquired immunity.

TL;DR: Ginsenoside Rg1 promoted cerebral angiogenesis through increasing the expression of VEGF via PI3K/Akt/mTOR signaling pathway after ischemic stroke through upregulated the expressions of V EGF, HIF-1α,PI3K, p-Akt, and p-mTOR.

TL;DR: Different treatment strategies for diabetes management starting from insulin therapy to synbiotics are discussed, including the combination of herbal phytoconstituents with synthetic drugs, synthetic drug combinations, novel drug delivery systems for insulin are highlighted.

TL;DR: It is proposed that liraglutide suppresses NLRP3 inflammasome-induced hepatocyte pyroptosis via mitophagy to slow the progression of NASH.

TL;DR: The beneficial effect of betaine in MCD‐induced NAFLD is associated with the reduction of liver oxidative stress, inflammation, and apoptosis, and the increase in cytoprotective Akt/mTOR signaling and autophagy.

TL;DR: There is ample evidence suggesting that sesamol possesses potent anti-cancer properties in vitro and in vivo, and a thorough understanding of the molecular targets of sesAMol and the mechanisms of action underlying its anti- cancer effects is necessary for possible employment of sESamol as a chemotherapeutic agent in cancer prevention and therapy.

TL;DR: The pharmacological effects of anthocyanins and C3G in CNS disorders as well as their possible mechanisms are summarized to get a clear insight into the role of anthcyanins in the CNS.

TL;DR: Cinnamaldehyde and eugenol were found to exert potent anti‐inflammatory and anti‐oxidant effects on the PBMC culture of RA patients, and may be used as an adjunct in the management of RA.

TL;DR: CBD treatment decreased the inflammatory and remodelling processes in the model of allergic asthma, and there was a significant and inverse correlation between CB1 levels and lung function in asthmatic patients.

TL;DR: Collectively, quercetin inhibited cell viability, migration and invasion by regulating miR‐16 and HOXA10 in oral cancer cells, indicating that quercETin might be promising for treatment of oral cancer.

TL;DR: This review focuses on studies with molecular‐based approaches involving MDD to obtain an integrated, more detailed and comprehensive view of the brain changes produced by this disorder and its treatment and how the Central Nervous System (CNS) produces neuroplasticity to orchestrate adaptive defensive behaviors.

TL;DR: Cenobamate significantly shifted the steady-state fast inactivation relationship toward a hyperpolarizing range, indicating that cenobamine binds to voltage-gated Na+ channels at the inactivated state with a higher affinity.

TL;DR: In this article, the main studies about clinical effects of several target inhibitors are reviewed, describing properly the most prominent mechanisms of both intrinsic and acquired resistance.

TL;DR: The pharmacological development of icariin as well as its possible mechanisms in prevention and/ or therapy of disorders afflicting the nervous system are summarized in hope of expanding the knowledge about the preventive and/or therapeutic effect of icARIin in brain disorders.

TL;DR: The behavioral, biochemical and histological outcomes of the present study demonstrates that diadzein has significant anti‐mucositis properties in 5‐FU induced mucositis model, and the attenuative potential of diadZEin might be due to inhibition of oxidative stress and inflammatory mediators.

TL;DR: The role of ER stress and misfolded protein response signaling in the pathogenesis of metabolic syndrome is discussed, highlighting the main functions of UPR components and the use of novel small molecular chemical chaperones, considered as modulators of ER Stress.

TL;DR: SNHG7 promoted breast cancer tumorigenesis and progression by sponging miR-34a through EMT initiation and the Notch-1 pathway and contribute to a better understanding of breast cancer pathogenesis and the theoretical fundamental basis for treatment.

TL;DR: The use of ketamine has returned; to its former glory, but the drug must be used with caution because still the mechanisms by which it executes its functions and long-term effects of its use are not fully known.

TL;DR: Results indicated that sevoflurane suppressed cell migration and invasion through regulating ERK/MMP‐9 pathway via miR‐203/Robo1 in CRC cells, indicating important clinical implications for anesthetic agents to prevent metastasis in CRC.

TL;DR: Findings suggest that XIST may facilitate the progression of RB through acting as a ceRNA for miR‐101 to mediate the expression of ZEB1 and ZEB2.

TL;DR: Results indicate that quercetin inhibited the growth of A375SM melanoma cells through apoptosis and thus can be regarded as a new and effective chemo-preventive or therapeutic agent.

TL;DR: The current knowledge on the roles of different sialidases in pathological conditions is summarized and may have beneficial effects in several pathologies.

TL;DR: It is demonstrated that PLA possessed the potential to prevent lipid accumulation in OA-induced HepG2 cells via upregulating the AMPK/SIRT1 signaling pathway, which supported the development of new drug candidate against non-alcoholic steatohepatitis.

TL;DR: This review summarizes the salient features of APP processing focusing on APP, the canonical secretases as well as the novel secretases and the cleavage products with an update of the recent developments.

TL;DR: It is possible for harmine to be used to clinically treat acute kidney injury through reducing oxidative stress and inflammation responses and the involved underlying mechanisms might be related to inhibition of the TLR4‐NF‐&kgr;B pathway and NLRP3 inflammasome pathway.

TL;DR: An up to date knowledge of the available small molecule inhibitors of Bcl-2, their discovery, synthesis, current clinical and pre-clinical status is summarized.