Yuanyuan Guo

TL;DR: TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, adjuvant in vaccine systems, nutrition supplement, plasticizer of film, anticancer reagent and so on are discussed.

TL;DR: The nanovaccine prolonged tumor-occurring time, inhibited tumor growth, and suppressed tumor metastasis in prophylactic, therapeutic, and metastatic melanoma models, respectively, and it was revealed that nanvaccine effectively enhanced IFN-γ secretion and CD8(+) T cell response.

TL;DR: A biomimetic nanogel with tumor microenvironment responsive property is developed for the combinatorial antitumor effects of chemotherapy and immunotherapy and can achieve "nanosponge" property for delivering immunotherapeutic agent interleukin-2 without reducing the bioactivity.

TL;DR: Both the pharmacokinetic properties and in vivo antitumor activity of DOX-loaded CT NPs were improved compared with Adriamycin, and the potential of these NPs to act as an oral delivery system was investigated.

TL;DR: In vivo evaluation of the TPGS-S- S-PTX prodrug exhibited an extended half-life, increased AUC (area under the concentration-time curve), enhanced tumor distribution and significant tumor growth inhibition with reduced side effects as compared to Taxol and TPGs-C-C -PTX.