Yuling Bao

TL;DR: The nanovaccine prolonged tumor-occurring time, inhibited tumor growth, and suppressed tumor metastasis in prophylactic, therapeutic, and metastatic melanoma models, respectively, and it was revealed that nanvaccine effectively enhanced IFN-γ secretion and CD8(+) T cell response.

TL;DR: In vivo evaluation of the TPGS-S- S-PTX prodrug exhibited an extended half-life, increased AUC (area under the concentration-time curve), enhanced tumor distribution and significant tumor growth inhibition with reduced side effects as compared to Taxol and TPGs-C-C -PTX.

TL;DR: A pH-sensitive prodrug was introduced by conjugating anticancer drug, doxorubicin (DOX), onto d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) via a cleavable Schiff base linkage to form a simple but multifunctional hybrid micelle system, which can realize high drug loading capability and biocompatibility.

TL;DR: The formulated LZnP nano-vaccine exhibited antitumor immunity as the secretion of cytokines in vitro and increased CD8(+) T cell response from IFN-γ ELISPOT analysis ex vivo, indicating that co-delivery of tumor antigens along with adjuvant may be an optimized strategy for tumor immunotherapy.

TL;DR: It is demonstrated that antigenic MVs with chemotherapeutics possess great potential in cancer immunochemotherapy and can extend the survival of 60% mice more than 150 d without ascites even after rechallenging the tumor twice.