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Yuanyuan Guo
Researcher at Huazhong University of Science and Technology
Publications - 19
Citations - 1703
Yuanyuan Guo is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Immunotherapy & Medicine. The author has an hindex of 10, co-authored 15 publications receiving 1293 citations.
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Journal ArticleDOI
The applications of Vitamin E TPGS in drug delivery.
TL;DR: TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, adjuvant in vaccine systems, nutrition supplement, plasticizer of film, anticancer reagent and so on are discussed.
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Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma.
Yuanyuan Guo,Dong Wang,Qingle Song,Tingting Wu,Xiangting Zhuang,Yuling Bao,Miao Kong,Yan Qi,Songwei Tan,Zhiping Zhang +9 more
TL;DR: The nanovaccine prolonged tumor-occurring time, inhibited tumor growth, and suppressed tumor metastasis in prophylactic, therapeutic, and metastatic melanoma models, respectively, and it was revealed that nanvaccine effectively enhanced IFN-γ secretion and CD8(+) T cell response.
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Tumor Microenvironment Responsive Nanogel for the Combinatorial Antitumor Effect of Chemotherapy and Immunotherapy
Qingle Song,Yijia Yin,Lihuan Shang,Tingting Wu,Dan Zhang,Miao Kong,Yongdan Zhao,Yangzhou He,Songwei Tan,Yuanyuan Guo,Zhiping Zhang +10 more
TL;DR: A biomimetic nanogel with tumor microenvironment responsive property is developed for the combinatorial antitumor effects of chemotherapy and immunotherapy and can achieve "nanosponge" property for delivering immunotherapeutic agent interleukin-2 without reducing the bioactivity.
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Chitosan-g-TPGS nanoparticles for anticancer drug delivery and overcoming multidrug resistance.
Yuanyuan Guo,Min Chu,Songwei Tan,Shuang Zhao,Hanxiao Liu,Ben Oketch Otieno,Xiangliang Yang,Chuanrui Xu,Zhiping Zhang +8 more
TL;DR: Both the pharmacokinetic properties and in vivo antitumor activity of DOX-loaded CT NPs were improved compared with Adriamycin, and the potential of these NPs to act as an oral delivery system was investigated.
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d-α-Tocopherol Polyethylene Glycol Succinate-Based Redox-Sensitive Paclitaxel Prodrug for Overcoming Multidrug Resistance in Cancer Cells
TL;DR: In vivo evaluation of the TPGS-S- S-PTX prodrug exhibited an extended half-life, increased AUC (area under the concentration-time curve), enhanced tumor distribution and significant tumor growth inhibition with reduced side effects as compared to Taxol and TPGs-C-C -PTX.