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Yuanyuan Tong
Publications - 4
Citations - 4
Yuanyuan Tong is an academic researcher. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 4 publications receiving 4 citations.
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Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis.
Xue Ming Chen,Fan-Cui Meng,Jingtian Zhang,Zijian Zhang,Xuan Ye,Weikun Zhang,Yuanyuan Tong,Xinrui Ji,R Xu,Xiao-Li Xu,Qixiu You,Zheng-Yu Jiang +11 more
TL;DR: In this article , a BRD4 inhibitor with a new scaffold, 27, was presented as a potential candidate for the treatment of sepsis, which decreased LPS-induced NO production and expression of the pro-inflammatory factors IL-6, IL-1β and TNF-α.
Journal ArticleDOI
ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.
TL;DR: In this paper , the authors constructed a chimeric molecule C2, which consists of an Nrf2-binding element and a CRBN ligand, as a first-in-class NRF2 degrader.
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Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis
TL;DR: In this paper , a series of hybrid derivatives were synthesized by connecting an inhibitor of Keap-Nrf2 protein-protein interaction with two well-established H2S-donor moieties, respectively, via an ester linker, to find a drug candidate more effective for the UC treatment.
Journal ArticleDOI
Discovery of 1H-Imidazo[4,5-b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
Xuetao Chen,Danyan Cao,Chih-Yin Liu,Fan-Cui Meng,R Xu,Yuanyuan Tong,Wenjing Kang,Qi-Chao Bao,Jingkang Shen,Bing Xiong,Qidong You,Zheng-Yu Jiang +11 more
TL;DR: In this paper , a selective and potent inhibitor of the bromodomain and extra-terminal (BET) proteins for reducing neuroinflammation and excitability to treat neuropathic pain was reported.