Yue Yuan

TL;DR: The difference between serum and plasma miRNA concentration showed some associations with miRNA from platelets, which may indicate that the coagulation process may affect the spectrum of extracellular miRNA in blood.

TL;DR: The possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health is raised.

TL;DR: This study illustrates the possibility of using circulating RNAs to assess global effects of therapeutics by conducting an RNA profiling study using the well-characterized acetaminophen overdose mouse model on liver and plasma with microarray and next-generation sequencing platforms.

TL;DR: It is demonstrated that quantification of organ-enriched proteins in the blood offers a new strategy to find biomarkers for diagnosis and assessment of drug-induced liver injury (and presumably the assessment of other liver diseases).

TL;DR: The results showed that, as in humans, the lines that comprise the Collaborative Cross exhibited wide genetic variation in response to this drug, which suggests that the genetically diverse collaborative Cross animals may reveal drug effects that might be missed if a study were based on a conventional mouse strain.