David Huang

TL;DR: The changes in miRNA spectra observed in the urine samples from patients with different urothelial conditions demonstrates the potential for using concentrations of specific miRNAs in body fluids as biomarkers for detecting and monitoring various physiopathological conditions.

TL;DR: The possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health is raised.

TL;DR: Urinary microRNA profiles differ across the different stages of diabetic nephropathy, and combining expression ratios of microRNAs with formal inferences about their predicted mRNA targets and associated biological pathways may yield useful markers for early diagnosis and risk stratification of DN in T1D by inferring the alteration of renal molecular processes.

TL;DR: The systems genomics approach showed consistency across different biological levels (DNA, RNA and protein concentrations).

TL;DR: This study illustrates the possibility of using circulating RNAs to assess global effects of therapeutics by conducting an RNA profiling study using the well-characterized acetaminophen overdose mouse model on liver and plasma with microarray and next-generation sequencing platforms.