Yuejun Shi

TL;DR: Comparisons of amino acid sequences of several representative CoVs reveal that pAPN is likely not a critical functional receptor for PDCoV, although it is involved in PD coV infection.

TL;DR: The anti-PEDV effect of the broad-spectrum inhibitor GC376 (targeting 3Cpro or 3CLpro of viruses in the picornavirus-like supercluster) was highly effective and exerted similar inhibitory effects on two PEDV strains.

TL;DR: Zhang et al. as discussed by the authors evaluated the antiviral activity of a remdesivir parent nucleotide analog, GS441524, which targets the coronavirus RNA-dependent RNA polymerase enzyme, and GC376, which targeted its main protease, using a mouse-adapted SARS-CoV-2 infected mouse model.

TL;DR: It is proposed that during RABV infection, P binds to L9 that translocates from the nucleus to the cytoplasm, inhibiting the initial stage of R ABV transcription.

TL;DR: The first dimeric structure of the arterivirus nsp11 from PRRSV is reported, which exhibits a unique structure and assembles into an asymmetric dimer whose structure is completely different from the hexameric structure of coronav virus nsp15.