Zhe Jiao

TL;DR: Zhang et al. as discussed by the authors evaluated the antiviral activity of a remdesivir parent nucleotide analog, GS441524, which targets the coronavirus RNA-dependent RNA polymerase enzyme, and GC376, which targeted its main protease, using a mouse-adapted SARS-CoV-2 infected mouse model.

TL;DR: Low-dose combined application of GC376 and GS441524 could effectively protect mice from HRB26M infection in the upper and lower respiratory tracts and should be developed and considered for future clinic practice.

TL;DR: Wang et al. as discussed by the authors constructed a field type I FIPV full-length cDNA clone, pBAC-QS, corresponding to the isolated FipV QS, and established and rescued a recombinant virus, designated rQS-79.

TL;DR: In this article, the authors showed that coinfection of porcine deltacoronavirus (PDCoV) and porcINE epidemic diarrhea virus (PEDV) can alter PEDV tropism that may affect the outcome of viral disease in piglets.

TL;DR: The research explains the evolutionary characteristics of coronaviruses under antiviral drugs, which is helpful for a more comprehensive understanding of the molecular basis of virus resistance and provides important basic data for the effective prevention and control of CoVs.