Y
Yuelei Zhang
Researcher at Shanghai Jiao Tong University
Publications - 14
Citations - 863
Yuelei Zhang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Osteocalcin & Mesenchymal stem cell. The author has an hindex of 11, co-authored 14 publications receiving 613 citations.
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Journal ArticleDOI
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model.
TL;DR: SMSC-140-Exos enhanced the proliferation and migration of ACs without damaging ECM secretion in vitro, while in vivo, SMSC- 140- exos successfully prevented OA in a rat model.
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Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration
TL;DR: The therapeutic effects of PRP on cartilage regeneration could be enhanced by removing leukocytes to avoid the activation of the NF-κB pathway, and PRP without concentratedLeukocytes may be more suitable for the treatment of articular cartilage lesions.
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Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in promoting repair of bone defects
Wenjing Yin,Xin Qi,Yuelei Zhang,Jiagen Sheng,Zhengliang Xu,Shi-Cong Tao,Xuetao Xie,Xiao-Lin Li,Changqing Zhang +8 more
TL;DR: L-PRP treatment resulted in the activation of the NF-κB pathway in HBMSCs and EaHy926 in vitro while the postoperative delivery of caffeic acid phenethyl ester enhanced the histological results of the implantation of L- PRP preprocessed β-TCP in vivo.
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Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model
TL;DR: Vitamin K2 has the ability to promote angiogenesis in vitro and to ameliorate vessels of the femoral head in glucocorticoid-treated rats in vivo, indicating that Vitamin K2 is a promising drug that may be used to prevent steroid-induced ONFH.
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Vitamin K2 Prevents Glucocorticoid-induced Osteonecrosis of the Femoral Head in Rats.
TL;DR: In this article, the authors investigated how bone marrow-derived stem cells in the presence of methylprednisolone proliferate and differentiate, specifically examining osteogenic-related proteins, including Runx2, alkaline phosphatase and osteocalcin.