T
Ting Yuan
Researcher at Shanghai Jiao Tong University
Publications - 32
Citations - 1493
Ting Yuan is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Platelet-rich plasma & Medicine. The author has an hindex of 11, co-authored 24 publications receiving 924 citations.
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Journal ArticleDOI
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model.
TL;DR: SMSC-140-Exos enhanced the proliferation and migration of ACs without damaging ECM secretion in vitro, while in vivo, SMSC- 140- exos successfully prevented OA in a rat model.
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Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model.
TL;DR: This study is the first to show that exosomes derived from PRP (PRP-Exos) may exert the function of PRP, and provides evidence of the probable molecular mechanisms underlying the PRP effect on healing of chronic ulcers and describes a promising resource of growth factors from exosome without species restriction.
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Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway.
TL;DR: Results indicate that PRP-Exos have the capability to prevent GC-induced apoptosis in a rat model of ONFH by promoting Bcl-2 expression via the Akt/Bad/B cl-2 signal pathway under ER stress.
Journal ArticleDOI
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
Yan Zhou,Dong Yang,Qingcheng Yang,Xiao-Bin Lv,Wentao Huang,Zhenhua Zhou,Yaling Wang,Zhichang Zhang,Ting Yuan,Xiaomin Ding,Li-Na Tang,Jianjun Zhang,Junyi Yin,Yujing Huang,Wenxi Yu,Yonggang Wang,Chenliang Zhou,Yang Su,Aina He,Yuanjue Sun,Zan Shen,Bin-Zhi Qian,Wei Meng,Jia Fei,Yang Yao,Xinghua Pan,Peizhan Chen,Haiyan Hu +27 more
TL;DR: TIGIT blockade enhances the cytotoxicity effects of the primary CD3+ T cells with high proportion of TIGIT+ cells against osteosarcoma, and provides potential therapeutic targets for osteosARcoma.
Journal Article
[Therapeutic effectiveness of intra-knee-articular injection of platelet-rich plasma on knee articular cartilage degeneration].
TL;DR: Intra-knee-articular injection of PRP to treat knee articular cartilage degeneration is safe, which can alleviate symptoms of pain and swelling and improve the quality of life of patients; however, further data of large samples and long-term follow-up are needed to confirm the safety and effectiveness.