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Yuerong Zhu
Researcher at University of Iowa
Publications - 4
Citations - 1823
Yuerong Zhu is an academic researcher from University of Iowa. The author has contributed to research in topics: Cyclin T1 & P-TEFb. The author has an hindex of 4, co-authored 4 publications receiving 1770 citations.
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Journal ArticleDOI
Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro
Yuerong Zhu,T Pe'ery,Junmin Peng,Yegnanarayana Ramanathan,Nick F. Marshall,Tricia K. Marshall,Brad A. Amendt,Michael B. Mathews,David H. Price +8 more
TL;DR: The cloning of the small subunit of Drosophila P-TEFb and the finding that it encodes a Cdc2-related protein kinase is reported, indicating that P- TEFb is a Tat-associated kinase (TAK) and PITALRE associated with the activation domain of HIV-1 Tat.
Journal ArticleDOI
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.
Helena S.Y. Mancebo,Gary Lee,John A. Flygare,Joanne E. Tomassini,Percy Luu,Yuerong Zhu,Junmin Peng,Carol Blau,Daria J. Hazuda,David H. Price,Osvaldo Flores +10 more
TL;DR: It is suggested that P-TEFb represents an attractive target for the development of novel HIV therapeutics after a panel of structurally diverse inhibitors indicated that their target is the human homolog of Drosophila positive transcription elongation factor b.
Journal ArticleDOI
Identification of multiple cyclin subunits of human P-TEFb
TL;DR: This work demonstrates the cloning of multiple cyclin subunits of human P-TEFb (T1 and T2) and indicates that cyclin T1 andT2 were associated withCDK9 in a mutually exclusive manner and that almost all CDK9 was associated with either cyclinT1 or T2.
Journal ArticleDOI
Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.
Wimmer J,Koh Fujinaga,Ran Taube,Thomas P. Cujec,Yuerong Zhu,Junmin Peng,David H. Price,B. Matija Peterlin +7 more
TL;DR: It is found that of these three cyclins, only cyclin T1 is encoded on human chromosome 12 and is responsible for its effects in CHO cells and became permissive for infection by and replication of HIV after introducing appropriate receptors and human cyclinT1 into CHO cells.