Showing papers in "Virology in 1999"

TL;DR: Geminiviruses are a group of plant viruses characterized by a genome of circular single-stranded DNA encapsidated in twinned quasi-isometric particles and recombination is very frequent and occurs between species and within and across genera.

TL;DR: Analysis of the sequences of all eight RNA segments of the influenza A/G oose/Guangdong/1/96 virus revealed that the hemagglutinin (HA) gene of the virus was genetically similar to those of the H5N1 viruses isolated in Hong Kong in 1997, but the remaining genes showed greater similarity to other avian influenza viruses.

TL;DR: F influenza virus pathogenicity is discussed, with an emphasis on the role of HA0 cleavage as a determining factor.

TL;DR: It is proposed that this chromosomal association of the KSHV genome is mediated by LANA and involves a tethering mechanism by which viral episomes are linked to host chromatin through simultaneous interaction with host chromosomal proteins including histone H1 and cis-acting K SHV DNA elements.

TL;DR: A number of homologs of genes not previously reported for baculoviruses were identified, including a predicted protein with homology to DNA ligases and another that has motifs most closely related to a yeast mitochondrial helicase.

TL;DR: There was an inverse relationship between expression of GFP and the heterologous coat protein genes that was reflected in accumulation of the respective mRNAs and proteins, and the most effective vector contained sequences encoding the coat protein subgenomic mRNA promoter, coat protein ORF, and 3' nontranslated region from tobacco mild green mosaic virus U5.

TL;DR: This work affirms the existence of a conserved complement of poxvirus-specific core genes and expands the growing repertoire of virus genes that confer the unique capacity of each poxVirus family member to counter the immune responses of the infected host.

TL;DR: It is demonstrated that GBP-1 mediates an antiviral effect against VSV and EMCV and plays a role in the IFN-mediated antiviral response against these viruses.

TL;DR: TTV strains with extremely high sequence divergence prevailing in healthy individuals and frequent mixed infection with TTV strains of distinct genotypes are indicated.

TL;DR: The data suggest that a nanovirus-like DNA has become whitefly-transmissible as a result of its association with a geminivirus and that cotton leaf curl disease may result from a mutually dependent relationship that has developed between members of two distinct DNA virus families that share a similar replication strategy.

TL;DR: C cultured embryonic fibroblasts lacking RNase L, PKR, or both proteins were still able to mount a substantial residual antiviral response against encephalomyocarditis virus or vesicular stomatitis virus after IFN-alpha treatments.

TL;DR: Cell fractionation analysis revealed that hVAP-33 is predominantly associated with the ER, the Golgi complex, and the prelysosomal membrane, consistent with its potential role in intracellular membrane trafficking.

TL;DR: The CPMV capsid was permeable to cesium ions, leading to a disturbance of the beta-annulus inside a channel-like structure, suggesting an ion channel, and the P6(1)22 crystal structure was solved by molecular replacement with the C PMV model determined in the cubic cell.

TL;DR: The results suggest that HPV, via E7, targets p48, resulting in the loss of IFNalpha-mediated signal transduction and may provide a means by which HPV can avoid the innate immune system.

TL;DR: The data indicate that GP64 is an important and limiting factor in BV production, and the GP64 CTD is not essential for production of infectious BV, but removal of the CTD results in a measurable reduction in budding efficiency.

TL;DR: It is proposed that GroEL of B. tabaci protects the virus from destruction during its passage through the haemolymph, suggesting that by complexing the GoEL homologue, the antibody disturbed interaction with TYLCV, leading to degradation of the virus.

TL;DR: The pTV vector containing extensively modified long terminal repeats of pTV exhibited a self-inactivating phenotype after transduction, transduced both dividing and nondividing cells at similar efficiencies, and produced vector titers twice as high as that of the wild-type construct.

TL;DR: The complete Npro coding sequences were determined for 16 pestiviruses isolated from cattle, pig, and several wild ruminant species including reindeer, bison, deer, and bongo, and Interestingly, the isolates from reindeers and bison are distinct from the established pestivirus species.

TL;DR: The nucleotide sequence of the Xestia c-nigrum granulovirus genome was determined and found to comprise 178,733 bases with a G+C content of 40.7%.

TL;DR: This report documents the first instance of integrated DNA of a nonintegrating virus giving rise to an episomal viral infection and identifies tissue culture as a possible trigger for the infection, raising the question of whether similar activatable viral sequences exist in the genomes of other plants and animals.

TL;DR: Specific competition by GP64solOp for virion binding suggests that the GP64 protein is a host cell receptor-binding protein.

TL;DR: The construction of an infectious cDNA clone representing a second major HCV genotype, genotype 2, is reported, which encodes the consensus polyprotein of strain HC-J6(CH), genotypes 2a.

TL;DR: To identify cellular factors with a possible role in HCV replication and pathogenesis, a human liver cDNA library was screened in a yeast two-hybrid assay to identify cellular proteins that interact with the viral core protein.

TL;DR: The production of an anti-envelope hyperimmune serum with EEV neutralizing activity is reported and it is suggested that antibodies to a specific protective epitope or epitopes on protein B5R are able to prevent EEV infection.

TL;DR: The results support the feasibility of producing edible vaccines in transgenic forage plants, such as alfalfa, commonly used in the diet of domestic animals even for those antigens for which a systemic immune response is required.

TL;DR: The results provide direct evidence for recombination between distinct families of plant single-stranded DNA viruses and suggest that coinfection by geminivirus and nanovirus-like pathogens may be a widespread phenomenon.

TL;DR: In this article, the authors reported integrated sequences that possibly lead to a plant pararetrovirus episomal infection by a mechanism differing markedly from animal retroviral systems, by probing stretched DNA fibers.

TL;DR: BC-1-Ep/SL cells, an immortalized human foreskin keratinocyte cell line, is used to recreate the HPV-16 life cycle and shows many characteristics of the early-passage HFKs including the ability to stratify and terminally differentiate in an organotypic raft culture system.

TL;DR: The findings indicate that growth of human influenza viruses in CE is restricted because of their inefficient binding to receptors on CAM cells and that gangliosides can play an important role in virus binding and/or penetration.