Yuguan Wen

TL;DR: The newly developedLC-MS/MS method was successfully used to determine concentrations of tryptophan, kynurenine and kynurenic acid in serum from 26 healthy volunteers and 54 patients with depression, showing linearity of analyte to internal standard peak area ratios.

TL;DR: In this article, the authors analyzed the current status and developing trends in Gut microbiota research in the depression field through bibliometric and visual analysis, which may help researchers choose suitable cooperators or journals, and promote their research illustrating the underlying molecular mechanisms of depression, including its etiology, prevention, and treatment.

TL;DR: XYS reversed the abnormalities of the tryptophan-kynurenine metabolic pathways in depressed rats and achieved an excellent antidepressant effect.

TL;DR: The rapid, sensitive, and selective liquid chromatography-electrospray ionization-tandem mass spectrometry method (LC-ESI-MS/MS) for the simultaneous estimation and pharmacokinetic investigation of glimepiride and pioglitazone in human plasma has been developed and fully validated.

TL;DR: In this paper, a bibliometric analysis aimed to provide a first glimpse into the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders, including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state.