Yujean Lee

TL;DR: In this paper, a two-in-one CAR T approach was proposed, where two checkpoint receptors were downregulated simultaneously by a dual short hairpin RNA cassette integrated into a CAR vector, and the PD-1/TIGIT-downregulated CAR T cells generated from diffuse large B cell lymphoma patient-derived T-cells also showed robust antitumor activity and significantly improved persistence in vivo.

TL;DR: In this article, a novel CMOS readout circuit for a satellite infrared time delay and integration (TDI) array is proposed, and a dead pixel elimination circuit solving a critical problem of the TDI scheme is integrated within a chip.

TL;DR: In this article, a pixelwise readout circuit for microbolometer focal plane arrays (FPAs) is proposed, and a current mirroring injection input circuit that is suitable for a pixel-wise architecture and has high responsivity is proposed.

TL;DR: In this paper, a pixel-level analog-to-digital converter (ADC) was proposed for 320 × 240 microbolometer focal plane arrays (FPAs) to decrease the thermal noise.

TL;DR: A lentiviral two-in-one CAR T approach in which two checkpoint receptors are downregulated simultaneously by a dual short-hairpin RNA (shRNA) cassette integrated into a CAR vector demonstrates that the cell-intrinsic PD-1/TIGIT dual downregulation strategy may prove effective in overcoming immune checkpoint-mediated resistance in CAR T therapy.