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Yuji Zhang
Researcher at University of Maryland, Baltimore
Publications - 84
Citations - 2148
Yuji Zhang is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 23, co-authored 74 publications receiving 1813 citations. Previous affiliations of Yuji Zhang include University of Washington & University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Calculating Sample Size Estimates for RNA Sequencing Data
TL;DR: A model is developed to estimate the statistical power needed to identify differentially expressed genes from RNA-Seq experiments, finding evidence that 91% ± 4% of all annotated genes are sequenced at a frequency of 0.1 times per million bases mapped, regardless of sample source.
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Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer.
TL;DR: A model of ERα-negative/basal-like DCIS is examined and restoration of miR-140 via a genetic approach or with the dietary compound sulforaphane decreased SOX9 and ALDH1, and reduced tumor growth in vivo, suggesting that the miR -140 pathway may be a promising target for preventative strategies in patients with basal- like DCIS.
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APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma
Brandon Leonard,Steven N. Hart,Michael B. Burns,Michael A. Carpenter,Nuri A. Temiz,Anurag Rathore,Rachel Isaksson Vogel,Jason B. Nikas,Emily K. Law,William L. Brown,Ying Li,Yuji Zhang,Matthew J. Maurer,Ann L. Oberg,Julie M. Cunningham,Viji Shridhar,Debra A. Bell,Craig April,David Bentley,Marina Bibikova,R. Keira Cheetham,Jian-Bing Fan,Russell J. Grocock,Sean Humphray,Zoya Kingsbury,John F. Peden,Jeremy Chien,Elizabeth M. Swisher,Lynn C. Hartmann,Kimberly R. Kalli,Ellen L. Goode,Hugues Sicotte,Scott H. Kaufmann,Reuben S. Harris +33 more
TL;DR: Wide variation in the expression of the DNA cytosine deaminase APOBEC3B is reported, with elevated expression in the majority of ovarian cancer cell lines and high-grade primary ovarian cancers, identifying a potential role for APOBec3B in serous ovarian cancer genomic instability.
Journal Article
Cutting Edge: CD40 Engagement Up-Regulates Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Lung Fibroblasts
TL;DR: It is demonstrated here that CD40 engagement on human lung fibroblasts dramatically increases proinflammatory PGE2 synthesis and is mediated through an induction of cyclooxygenase-2 (Cox-2) since Cox-2-selective inhibitors block the up-regulation.
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Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish.
TL;DR: Definition of the cardiac transcriptome and fetal gene program will facilitate systems biology studies of dilated cardiomyopathy in zebrafish and supports the use of zebra fish as a conserved vertebrate model.