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Yujiang Shi
Researcher at Harvard University
Publications - 28
Citations - 8199
Yujiang Shi is an academic researcher from Harvard University. The author has contributed to research in topics: Regulation of gene expression & Histone. The author has an hindex of 23, co-authored 24 publications receiving 7936 citations. Previous affiliations of Yujiang Shi include Brigham and Women's Hospital & University of Florida.
Papers
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PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TL;DR: In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.
Journal ArticleDOI
A DNA Vector-Based RNAi Technology to Suppress Gene Expression in Mammalian Cells
TL;DR: This work reports a technology that allows synthesis of small interfering RNAs from DNA templates in vivo to efficiently inhibit endogenous gene expression and demonstrates robust inhibition of several endogenous genes of diverse functions in mammalian cells.
Journal ArticleDOI
Coordinated histone modifications mediated by a CtBP co-repressor complex
Yujiang Shi,Jun-ichi Sawada,Guangchao Sui,El Bachir Affar,Johnathan R. Whetstine,Fei Lan,Hidesato Ogawa,Margaret Po-Shan Luke,Yoshihiro Nakatani,Yang Shi +9 more
TL;DR: The identification of a CtBP complex that contains the essential components for both gene targeting and coordinated histone modifications, allowing for the effective repression of genes targeted by CtBP is reported.
Journal ArticleDOI
Yin Yang 1 Is a Negative Regulator of p53
Guangchao Sui,El Bachir Affar,Yujiang Shi,Chrystelle Brignone,Nathan R. Wall,Peng Yin,Mary E. Donohoe,Margaret Po-Shan Luke,Dominica Calvo,Steven R. Grossman,Yang Shi +10 more
TL;DR: YY1 is identified as a potential cofactor for Hdm2 in the regulation of p53 homeostasis and a possible role for YY1 in tumorigenesis is suggested.
Journal ArticleDOI
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
Mamta Tahiliani,Pinchao Mei,Rui Fang,Thiago Leonor,Michael S. Rutenberg,Michael S. Rutenberg,Fumiko Shimizu,Jing Li,Anjana Rao,Yujiang Shi +9 more
TL;DR: It is proposed that loss of SMCX activity impairs REST-mediated neuronal gene regulation, thereby contributing toSMCX-associated X-linked mental retardation.