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Yukihiro Akeda
Researcher at Osaka University
Publications - 161
Citations - 2706
Yukihiro Akeda is an academic researcher from Osaka University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 26, co-authored 133 publications receiving 1985 citations.
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Journal ArticleDOI
Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients
Tomoya Hirose,Shigeto Hamaguchi,Naoya Matsumoto,Taro Irisawa,Masafumi Seki,Osamu Tasaki,Hideo Hosotsubo,Norihisa Yamamoto,Kouji Yamamoto,Yukihiro Akeda,Kazunori Oishi,Kazunori Tomono,Takeshi Shimazu +12 more
TL;DR: Investigation of relationships of the presence of NETs and Cit-H3 with the existence of bacteria in tracheal aspirate, SIRS, diagnosis, WBC count, and concentrations of IL-8, TNF-α, cf-DNA, lactate, and HMGB1 found no significant relationships.
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The EspB protein of enterohaemorrhagic Escherichia coli interacts directly with alpha-catenin.
Toshio Kodama,Yukihiro Akeda,Gengo Kono,Akira Takahashi,Akira Takahashi,Kinichi Imura,Tetsuya Iida,Takeshi Honda +7 more
TL;DR: It is concluded that EspB recruits α‐catenin at the EHEC adherence site by direct interaction, and that the recruitment of α‐ catenin is essential for EH EC‐induced A/E lesion formation.
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Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy
Shunsuke Mori,Yukitaka Ueki,Yukihiro Akeda,Naoyuki Hirakata,Motohiro Oribe,Yoshiki Shiohira,Toshihiko Hidaka,Kazunori Oishi +7 more
TL;DR: TCZ does not impair PPV23 immunogenicity in RA patients, whereas antibody responses may be reduced when TCZ is used as a combination therapy with MTX, which had a negative impact on vaccine efficacy.
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Genotypic Profile of Streptococcus suis Serotype 2 and Clinical Features of Infection in Humans, Thailand
Anusak Kerdsin,Surang Dejsirilert,Parichart Puangpatra,Saowalak Sripakdee,Koranan Chumla,Nitsara Boonkerd,Pitimol Polwichai,Susumu Tanimura,Dan Takeuchi,Tatsuya Nakayama,Shota Nakamura,Yukihiro Akeda,Marcelo Gottschalk,Pathom Sawanpanyalert,Kazunori Oishi +14 more
TL;DR: The ST1 and ST104 strains are capable of causing sepsis, but only the ST1 strains commonly cause meningitis, which is unique to Thailand.
Journal ArticleDOI
The Contribution of Suilysin to the Pathogenesis of Streptococcus suis Meningitis
Dan Takeuchi,Yukihiro Akeda,Tatsuya Nakayama,Anusak Kerdsin,Yasuteru Sano,Takashi Kanda,Shigeyuki Hamada,Surang Dejsirilert,Kazunori Oishi,Kazunori Oishi +9 more
TL;DR: The role of suilysin, a member of cholesterol-dependent cytolysins, in differential pathogenicity between ST1 and ST104 strains is investigated and it is suggested that it contributed to the higher bacterial density and enhanced inflammation in brain and increased mortality of meningitis in humans.