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Yukiko M. Yamashita
Researcher at Massachusetts Institute of Technology
Publications - 148
Citations - 8661
Yukiko M. Yamashita is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Stem cell & Asymmetric stem cell division. The author has an hindex of 44, co-authored 128 publications receiving 7840 citations. Previous affiliations of Yukiko M. Yamashita include University of Michigan & Yokohama City University.
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Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome
TL;DR: It is shown that dividing Drosophila male germline stem cells use intracellular mechanisms involving centrosome function and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitotic spindles perpendicular to the niche, ensuring a reliably asymmetric outcome.
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Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division
TL;DR: It is shown that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line.
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Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
Akio Yamashita,Tsung Cheng Chang,Yukiko M. Yamashita,Wenmiao Zhu,Zhenping Zhong,Chyi-Ying A. Chen,Ann-Bin Shyu +6 more
TL;DR: The results show that deadenylation is the key first step that triggers decay of both wild-type stable and nonsense codon–containing unstable β-globin mRNAs in mouse NIH3T3 fibroblasts.
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Centrosome misorientation reduces stem cell division during ageing
TL;DR: It is proposed that cell cycle arrest associated with centrosome misorientation functions as a mechanism to ensure asymmetric stem cell division, and that the inability of stem cells to maintain correct orientation during ageing contributes to the decline in spermatogenesis.
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Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.
Yasushi Saka,Takashi Sutani,Yukiko M. Yamashita,Shigeaki Saitoh,Masahiro Takeuchi,Yukinobu Nakaseko,Mitsuhiro Yanagida +6 more
TL;DR: Fission yeast temperature‐sensitive mutants cut3‐477 and cut14‐208 fail to condense chromosomes but small portions of the chromosomes can separate along the spindle during mitosis, producing phi‐shaped chromosomes.