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Yukinori Ikegami
Researcher at Keio University
Publications - 41
Citations - 979
Yukinori Ikegami is an academic researcher from Keio University. The author has contributed to research in topics: Internal medicine & Heart failure. The author has an hindex of 10, co-authored 32 publications receiving 855 citations. Previous affiliations of Yukinori Ikegami include National Institutes of Health.
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Journal ArticleDOI
Novel Cardiac Precursor‐Like Cells from Human Menstrual Blood‐Derived Mesenchymal Cells
Naoko Hida,Naoko Hida,Nobuhiro Nishiyama,Shunichiro Miyoshi,Shinichiro Kira,Kaoru Segawa,Taro Uyama,Taisuke Mori,Kenji Miyado,Yukinori Ikegami,Yukinori Ikegami,Chang Hao Cui,Tohru Kiyono,Satoru Kyo,Tatsuya Shimizu,Teruo Okano,Michiie Sakamoto,Satoshi Ogawa,Akihiro Umezawa +18 more
TL;DR: It is demonstrated that menstrual blood‐derived mesenchymal cells (MMCs) began beating spontaneously after induction, exhibiting cardiomyocyte‐specific action potentials, and appear to be a potential novel, easily accessible source of material for cardiac stem cell‐based therapy.
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Xenografted Human Amniotic Membrane–Derived Mesenchymal Stem Cells Are Immunologically Tolerated and Transdifferentiated Into Cardiomyocytes
Hiroko Tsuji,Shunichiro Miyoshi,Yukinori Ikegami,Naoko Hida,Hironori Asada,Ikuko Togashi,Junshi Suzuki,Masaki Satake,Hikaru Nakamizo,Mamoru Tanaka,Taisuke Mori,Kaoru Segawa,Nobuhiro Nishiyama,Junko Inoue,Hatsune Makino,Kenji Miyado,Satoshi Ogawa,Yasunori Yoshimura,Akihiro Umezawa +18 more
TL;DR: Because hAMCs have a high ability to transdifferentiate into cardiomyocytes and to acquire immunologic tolerance in vivo, they can be a promising cellular source for allograftable stem cells for cardiac regenerative medicine.
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The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells In Vitro
Nobuhiro Nishiyama,Shunichiro Miyoshi,Naoko Hida,Naoko Hida,Taro Uyama,Kazuma Okamoto,Yukinori Ikegami,Kenji Miyado,Kaoru Segawa,Masanori Terai,Michiie Sakamoto,Satoshi Ogawa,Akihiro Umezawa +12 more
TL;DR: UCBMSCs can be a promising cellular source for cardiac stem cell‐based therapy, since such cells can be obtained from younger populations and are being routinely utilized for clinical patients.
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SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent ICaL, [Ca2+]i transient, and APD increase in cardiomyocytes
Yoko Hagiwara,Shunichiro Miyoshi,Keiichi Fukuda,Nobuhiro Nishiyama,Yukinori Ikegami,Kojiro Tanimoto,Mitsushige Murata,Eiichi Takahashi,Kouji Shimoda,Toshio Hirano,Hideo Mitamura,Satoshi Ogawa +11 more
TL;DR: SHP2-mediated signaling cascade is essential for the LIF and IL-6+sIL-6r-dependent increase in I(CaL), [Ca(2+)](i) transient and APD.
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'Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells
Kazuma Okamoto,Shunichiro Miyoshi,Masashi Toyoda,Naoko Hida,Yukinori Ikegami,Hatsune Makino,Nobuhiro Nishiyama,Hiroko Tsuji,Chang Hao Cui,Kaoru Segawa,Taro Uyama,Daisuke Kami,Kenji Miyado,Hironori Asada,Kenji Matsumoto,Hirohisa Saito,Yasunori Yoshimura,Satoshi Ogawa,Ryo Aeba,Ryohei Yozu,Akihiro Umezawa +20 more
TL;DR: Placenta-derived human fetal cells may be useful for patients who cannot supply bone marrow cells but want to receive stem cell-based cardiac therapy, and the presence of electrical communication between the cells is suggested.