N
Nobuhiro Nishiyama
Researcher at Tokyo Institute of Technology
Publications - 297
Citations - 24010
Nobuhiro Nishiyama is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Micelle & Nanocarriers. The author has an hindex of 81, co-authored 269 publications receiving 21910 citations. Previous affiliations of Nobuhiro Nishiyama include National Institute for Materials Science & University of Tokyo.
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Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery.
TL;DR: Polymeric micelles are nanotechnology-based carrier systems that might exert the activity of potent bioactive compounds in a site-directed manner, ensuring their effectiveness and safety in the clinical use.
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Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.
Younsoo Bae,Nobuhiro Nishiyama,Shigeto Fukushima,Hiroyuki Koyama,Matsumura Yasuhiro,Kazunori Kataoka +5 more
TL;DR: In vitro and in vivo studies show that the micelles have the characteristic properties, such as an intracellular pH-triggered drug release capability, tumor-infiltrating permeability, and effective antitumor activity with extremely low toxicity.
Journal Article
Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice
Nobuhiro Nishiyama,Souichiro Okazaki,Horacio Cabral,Masaki Miyamoto,Yukio Kato,Yuichi Sugiyama,Kazuto Nishio,Yasuhiro Matsumura,Kazunori Kataoka +8 more
TL;DR: CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors, according to the passive targeting manner, and its utility as a tumor-targeted drug delivery system was investigated.
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Lactosylated poly(ethylene glycol)-sIRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
TL;DR: The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG-siRNA conjugates bearing acid-labile beta-thiopropionate linkages into polyion complex micelles through the mixing with poly(l-lysine).