Teruo Okano

TL;DR: Structural deformations produced by outer shell polymer structural change with temperature cycles through the LCST are proposed for the PBMA core possessing a lower T(g) than the outer shell PIPAAm LCST, while the PSt core retained its structure, regardless of outer shell changes.

TL;DR: In vivo high anticancer activity of this micelle-forming polymeric drug against P 388 mouse leukemia was obtained with less body weight loss than that seen with freeADR, due to low toxicity as compared with free ADR, and increased stability of the bound Adriamycin molecules in phosphate-buffered saline.

TL;DR: PEG-P[Asp(ADR)] expressed critical suppression of tumor growth and considerably prolonged life span of the treated mice and the stabilized circulation of ADR residue in blood by binding to the block copolymer was considered to result from the micellar structure which possesses the hydrated outer shell composed of the poly(ethylene glycol) chains.

TL;DR: A compilation of commentaries gives a historical perspective and current status of research covered in some of the most cited research articles in the history of the Journal of Controlled Release.

TL;DR: This newly developed culture system and the hiPS-CM sheets may provide a basis for the clinical use of hiPS cells in cardiac regeneration therapy and improve cardiac function after ischemic cardiomyopathy.