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Yukiyoshi Shirasaka
Researcher at Kyoto University
Publications - 36
Citations - 1306
Yukiyoshi Shirasaka is an academic researcher from Kyoto University. The author has contributed to research in topics: Epilepsy & Status epilepticus. The author has an hindex of 19, co-authored 36 publications receiving 1245 citations. Previous affiliations of Yukiyoshi Shirasaka include Veterans Health Administration & University of California, Los Angeles.
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Journal ArticleDOI
Mutations of Neuronal Voltage-gated Na+ Channel α1 Subunit Gene SCN1A in Core Severe Myoclonic Epilepsy in Infancy (SMEI) and in Borderline SMEI (SMEB)
Goryu Fukuma,Hirokazu Oguni,Yukiyoshi Shirasaka,Kazuyoshi Watanabe,Tasuku Miyajima,Sawa Yasumoto,Masaharu Ohfu,Takahito Inoue,Aruchalean Watanachai,Ryutaro Kira,Muneaki Matsuo,Hideki Muranaka,Fumiko Sofue,Bo Zhang,Sunao Kaneko,Akihisa Mitsudome,Shinichi Hirose +16 more
TL;DR: The aim of this study was to delineate the genetic correlation between core SMEI and SMEB and to estimate the frequency of mutations in both phenotypes.
Journal ArticleDOI
Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity.
Kazuaki Kanai,Shinichi Hirose,Hirokazu Oguni,Goryu Fukuma,Yukiyoshi Shirasaka,Tasuku Miyajima,Kazumaru Wada,Hiroto Iwasa,Shinichiro Yasumoto,M. Matsuo,Masahiro Ito,Akihisa Mitsudome,Sunao Kaneko +12 more
TL;DR: There was a significant phenotype-genotype relationship in generalized epilepsy with febrile seizures plus and severe myoclonic epilepsy of infancy with SCN1A missense mutations, suggesting more severe sodium channel dysfunctions including abnormal ion selectivity that are caused by mutations in the pore regions may be involved in the pathogenesis of SMEI.
Journal ArticleDOI
A human Dravet syndrome model from patient induced pluripotent stem cells
Norimichi Higurashi,Norimichi Higurashi,Taku Uchida,Christoph Lossin,Yoshio Misumi,Yohei Okada,Wado Akamatsu,Yoichi Imaizumi,Bo Zhang,Kazuki Nabeshima,Masayuki X. Mori,Shutaro Katsurabayashi,Yukiyoshi Shirasaka,Hideyuki Okano,Shinichi Hirose +14 more
TL;DR: The results indicate a functional decline in Dravet neurons, especially in the GABAergic subtype, which supports previous findings in murine disease models, where loss-of-function in GABAergic inhibition appears to be a main driver in epileptogenesis.
Journal ArticleDOI
Seizures, brain damage and brain development
TL;DR: A mechanism for Gower's dictum that "seizures beget seizures" is suggested and the importance of the interneurons of the dentate gyrus in epileptogenesis is highlighted.
Book ChapterDOI
Seizure-induced neuronal death in the immature brain.
Claude G. Wasterlain,Jerome Niquet,Kerry Thompson,Roger A. Baldwin,Hantao Liu,Raman Sankar,Andrey Mazarati,David E. Naylor,Hiroshi Katsumori,Lucie Suchomelova,Yukiyoshi Shirasaka +10 more
TL;DR: It is shown that seizure-induced epileptogenesis can occur in the developing brain, with some models which reliably lead to spontaneous seizures and chronic epilepsy in the vast majority of animals.