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Yuko Okamatsu-Ogura
Researcher at Hokkaido University
Publications - 77
Citations - 3623
Yuko Okamatsu-Ogura is an academic researcher from Hokkaido University. The author has contributed to research in topics: Brown adipose tissue & Adipose tissue. The author has an hindex of 18, co-authored 71 publications receiving 3046 citations.
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Journal ArticleDOI
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity
Masayuki Saito,Yuko Okamatsu-Ogura,Mami Matsushita,Kumiko Watanabe,Takeshi Yoneshiro,Junko Nio-Kobayashi,Toshihiko Iwanaga,Masao Miyagawa,Toshimitsu Kameya,Kunihiro Nakada,Yuko Kawai,Masayuki Tsujisaki +11 more
TL;DR: The findings, being against the conventional view, indicate the high incidence of metabolically active BAT in adult humans and suggest a role in the control of body temperature and adiposity.
Journal ArticleDOI
Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans.
Takeshi Yoneshiro,Sayuri Aita,Mami Matsushita,Yuko Okamatsu-Ogura,Toshimitsu Kameya,Yuko Kawai,Masao Miyagawa,Masayuki Tsujisaki,Masayuki Saito +8 more
TL;DR: The results suggest that decreased BAT activity may be associated with accumulation of body fat with age, and the adiposity‐related parameters showed some sex differences, but increased with age in the BAT‐negative group, in both sexes.
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Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation
Shigeki Shimba,Tomohiro Ogawa,Shunsuke Hitosugi,Yuya Ichihashi,Yuki Nakadaira,Munehiro Kobayashi,Masakatsu Tezuka,Yasuhiro Kosuge,Kumiko Ishige,Yoshihisa Ito,Kazuo Komiyama,Yuko Okamatsu-Ogura,Kazuhiro Kimura,Masayuki Saito +13 more
TL;DR: BMAL1 is a crucial factor in the regulation of energy homeostasis, and disorders of the functions of BMAL1 lead to the development of metabolic syndrome.
Journal ArticleDOI
Indispensable role of mitochondrial UCP1 for antiobesity effect of β3-adrenergic stimulation
Ken-ichi Inokuma,Yuko Okamatsu-Ogura,Asako Omachi,Yukiko Matsushita,Kazuhiro Kimura,Hitoshi Yamashita,Masayuki Saito +6 more
TL;DR: It was concluded that the anti-obesity effect of beta3-adrenergic stimulation is largely attributable to UCP1, but less toUCP2 and UCP3, and thereby to U CP1-dependent degradation of fatty acids released from white adipose tissue.
Journal ArticleDOI
Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men.
TL;DR: Given the apparent beneficial effects of some TRP agonists and bile acids on whole-body substrate and energy metabolism, the TRP/TGR5–BAT axis represents a promising target for combating obesity and related metabolic disorders in humans.