Y
Yuko Osugi
Researcher at Osaka University
Publications - 48
Citations - 1990
Yuko Osugi is an academic researcher from Osaka University. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 24, co-authored 46 publications receiving 1896 citations.
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Journal ArticleDOI
Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis
Yuko Osugi,Junichi Hara,Shinichi Tagawa,Kenji Takai,Gaku Hosoi,Yoshiko Matsuda,Hideaki Ohta,Hiroyuki Fujisaki,Michiko Kobayashi,Naoki Sakata,Keisei Kawa-Ha,Shintaro Okada,Akio Tawa +12 more
TL;DR: Overproduction of IL-10 was also observed indicating that a mechanism suppressing hyperactivation of Th1 cells and monocytes/macrophages functions in patients with this disease.
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Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes.
TL;DR: Several differences in the properties of blood CD11c(+) DCs, Mo-DCs, and ActMo- DCs are established, which suggest that blood DCs merit further consideration as DC preparations for clinical programs are evolved.
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Hepatocyte Growth Factor Is Constitutively Produced by Human Bone Marrow Stromal Cells and Indirectly Promotes Hematopoiesis
Kenji Takai,Junichi Hara,Kunio Matsumoto,Gaku Hosoi,Yuko Osugi,Akio Tawa,Shintaro Okada,Toshikazu Nakamura +7 more
TL;DR: It is shown that hepatocyte growth factor (HGF) is one such cytokine produced by human BM stromal cells and that it enhances hematopoiesis.
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Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in Japan
Shouichi Ohga,Kazuko Kudo,Eiichi Ishii,Satoshi Honjo,Akira Morimoto,Yuko Osugi,Akihisa Sawada,Masami Inoue,Ken Tabuchi,Nobuhiro Suzuki,Yasushi Ishida,Shinsaku Imashuku,Shunichi Kato,Toshiro Hara +13 more
TL;DR: Post‐transplant outcomes of hemophagocytic lymphohistiocytosis (HLH) patients were analyzed in Japan where Epstein–Barr virus (EBV)‐associated severe forms are problematic.
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Ganciclovir is effective for prophylaxis and treatment of human herpesvirus-6 in allogeneic stem cell transplantation
Sadao Tokimasa,Junichi Hara,Yuko Osugi,Hideaki Ohta,Yoichi Matsuda,Hiroyuki Fujisaki,Akihisa Sawada,Ji Yoo Kim,Junji Sashihara,Kiyoko Amou,Hiromi Miyagawa,Keiko Tanaka-Taya,Koichi Yamanishi,Shintaro Okada +13 more
TL;DR: GCV is effective for treating HHV-6 disease after allo-SCT in vivo and patients who received GCV for treatment of HHV -6 infection showed an improvement in symptoms and/or decrease of HHv-6 copy number.