Yumiko Yoshida

TL;DR: Results indicate that the central mechanism for PEDF inhibition of the AGE signaling to vascular permeability is by suppression of NADPH oxidase-mediated ROS generation and subsequent VEGF expression, which may offer a promising strategy for halting the development of diabetic retinopathy.

TL;DR: Pigment epithelium‐derived factor is the most potent inhibitor of angiogenesis in the mammalian eye, thus suggesting that PEDF may protect against proliferative diabetic retinopathy, and whether and how it could prevent the development of diabetic Retinopathy is investigated.

TL;DR: It is demonstrated that PEDF could inhibit neointimal formation via suppression of NADPH oxidase-mediated reactive oxygen species generation and suggested that substitution of PEDf may be a novel therapeutic strategy for restenosis after balloon angioplasty.

TL;DR: The present data suggest that PEDF could play a protective role against tubular injury in diabetic nephropathy by attenuating the deleterious effects of AGEs via down-regulation of RAGE expression.

TL;DR: It is suggested that pharmacological upregulation or substitution of PEDF may play a protective role against diabetic retinopathy by attenuating the deleterious effect of AGEs and blocking the superoxide-mediated NF-ĸB activation.