Yun Jiao

TL;DR: Biotinylated dextran amines (BDA) are highly sensitive tools for anterograde and retrograde pathway tracing studies of the nervous system and can, therefore, be readily used in ultrastructural studies.

TL;DR: This method was found to enhance immunolabeling in glutaraldehyde-fixed tissue that had been prepared for ultrastructural examination, without having a deleterious effect on the ultrastructure.

TL;DR: Results suggest that striatonigral neurons preferentially receive input from IT-type cortical neurons, whereas striatopallidal neurons receive greater input from PT- type cortical neurons.

TL;DR: The clear differences between these two corticostriatal neuron types in perikaryal size and laminar location in the cortex, and in the size and shape of their intrastriatal terminals, suggest that they may differ in the nature of their influence on the striatum.

TL;DR: The finding that huntingtin is not consistently found in striatal projection neurons but is abundant instriatal cholinergic interneurons (which survive in Huntington’s disease) suggests that the mutation in huntingtin that causes HD may not directly kill neurons.